Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute, Academy of Military Medical Sciences, Changchun 130122, P. R. China.
Biomater Sci. 2018 Oct 24;6(11):2918-2924. doi: 10.1039/c8bm00830b.
The NIR dye cyanine (Cy) is one of the most significant phototherapy agents (PTAs) due to its strong NIR absorbance, high thermal conversion capacity and good safety. However, its clinic application is seriously limited owing to its inherent properties as an organic dye, including low solubility, poor selectivity, and fast clearance. Thus, herein, we embed Cy into the zeolitic imidazolate framework-8 (Cy@ZIF-8) for antitumor photothermal therapy (PTT). The obtained Cy@ZIF-8 NPs not only have good water solubility and excellent photostability, but also exhibit strong NIR absorbance and great photothermal conversion efficiency. Especially, the Cy@ZIF-8 NPs efficaciously inhibit tumor growth and possess outstanding NIR imaging capacity both in vitro and in vivo. This work demonstrates the theranostic value of Cy@ZIF-8 NPs for imaging-guided PTT therapy, and also encourages the further study of other PTAs@ZIF-8 composites for better anticancer PTT.
近红外染料菁染料（Cy）是最重要的光疗剂（PTAs）之一，因为它具有很强的近红外吸收、高热转化能力和良好的安全性。然而，由于其作为有机染料的固有性质，包括低溶解度、选择性差和快速清除，其临床应用受到严重限制。因此，本文将 Cy 嵌入沸石咪唑酯骨架-8（Cy@ZIF-8）中用于抗肿瘤光热治疗（PTT）。所得的 Cy@ZIF-8 NPs 不仅具有良好的水溶性和优异的光稳定性，而且表现出强的近红外吸收和大的光热转换效率。特别是，Cy@ZIF-8 NPs 有效地抑制肿瘤生长，并具有优异的体外和体内近红外成像能力。这项工作证明了 Cy@ZIF-8 NPs 用于成像引导 PTT 治疗的治疗价值，并鼓励进一步研究其他 PTAs@ZIF-8 复合材料以实现更好的抗癌 PTT。
