Department of Medical Oncology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, Inner Mongolia Autonomous Region, P.R. China.
Eur Rev Med Pharmacol Sci. 2018 Sep;22(17):5519-5524. doi: 10.26355/eurrev_201809_15812.
Emerging evidence indicates that small nucleolar RNAs (snoRNAs) act crucial roles in oncogenesis. Herein, the aim of this study is to investigate the clinical value of SNORA21 expression in gastric cancer (GC).
The expression of SNORA21 was determined in 79 cases of GC tissues and adjacent normal tissues by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) analysis. The association between SNORA21 expression and clinicopathological features was analyzed by the chi-square test. The survival curves were calculated by the Kaplan-Meier method and log-rank test. Univariate and multivariate analyses were used to assess the prognostic value of SNORA21 expression.
Our results first demonstrated that SNORA21 expression was significantly upregulated in human GC tissues and cells compared to their corresponding adjacent normal tissues and GES-1 cells, respectively (p<0.05). Furthermore, elevated SNORA21 expression was significantly associated with distant metastasis (p<0.05) and lymph node metastasis (p<0.05) in GC patients. Kaplan-Meier survival plots demonstrated that higher SNORA21 expression was associated with poor disease-free survival (DFS) and overall survival (OS) rate, respectively. Univariate analysis and multivariate regression analysis indicated that a higher SNORA21 was an independent risk factor for prognosis in GC patients.
The current results indicate that SNORA21 expression may be served as a predictor of GC prognosis.
新兴证据表明，小核仁 RNA（snoRNA）在肿瘤发生中发挥关键作用。本研究旨在探讨 SNORA21 在胃癌（GC）中的表达的临床价值。
通过定量实时聚合酶链反应（qRT-PCR）分析，检测 79 例 GC 组织和相邻正常组织中 SNORA21 的表达。采用卡方检验分析 SNORA21 表达与临床病理特征的关系。采用 Kaplan-Meier 法和对数秩检验计算生存曲线。采用单因素和多因素分析评估 SNORA21 表达的预后价值。
我们的研究结果首次表明，与相应的相邻正常组织和 GES-1 细胞相比，SNORA21 在人 GC 组织和细胞中的表达明显上调（p<0.05）。此外，SNORA21 的高表达与 GC 患者的远处转移（p<0.05）和淋巴结转移（p<0.05）显著相关。Kaplan-Meier 生存曲线表明，SNORA21 表达水平越高，患者的无病生存（DFS）和总生存（OS）率越低。单因素和多因素回归分析表明，SNORA21 高表达是 GC 患者预后的独立危险因素。
本研究结果表明，SNORA21 表达可能作为 GC 预后的预测指标。
