Zhang Xinhai, Wang Chenglong, Xia Shujun, Xiao Fei, Peng Jianping, Gao Yuxuan, Yu Fengbin, Wang Chuandong, Chen Xiaodong
Department of Orthopedic Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200092, China.
Ultrasound Department, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025, China.
Genes Dis. 2022 Dec 26;10(5):2064-2081. doi: 10.1016/j.gendis.2022.11.018. eCollection 2023 Sep.
Small nucleolar RNAs (snoRNAs) play critical roles in various biological processes. The aberrant expression or depletion of snoRNAs is related to various diseases. In previous research, most of the snoRNAs were categorized as C/D box snoRNAs and H/ACA box snoRNAs, whose typical functions were thought of as regulation of 2'-O-ribose methylation and pseudouridylation of ribosome RNAs, respectively. However, in the past two decades, studies have revealed an increasing number of snoRNAs without specific targets or determined cell functions. These findings indicated that some potential roles of snoRNAs are still unknown. Numerous studies have indicated the correlation of snoRNAs with human diseases. SnoRNAs play various roles in abundant biological processes, and they have great potential in controlling human diseases. This new and rising field could benefit from investigations of the disease pathogenesis, biomarker identification, and the determination of novel therapeutic targets. This review summarized the reports on snoRNAs and the regulation of different diseases in recent years.
小核仁RNA（snoRNAs）在各种生物学过程中发挥着关键作用。snoRNAs的异常表达或缺失与多种疾病相关。在以往的研究中，大多数snoRNAs被归类为C/D盒snoRNAs和H/ACA盒snoRNAs，其典型功能分别被认为是对核糖体RNA的2'-O-核糖甲基化和假尿苷化的调控。然而，在过去二十年中，研究发现了越来越多没有特定靶点或明确细胞功能的snoRNAs。这些发现表明，snoRNAs的一些潜在作用仍然未知。大量研究表明snoRNAs与人类疾病相关。snoRNAs在丰富的生物学过程中发挥着各种作用，并且在控制人类疾病方面具有巨大潜力。这个新兴领域可能会从疾病发病机制的研究、生物标志物的鉴定以及新型治疗靶点的确定中受益。这篇综述总结了近年来关于snoRNAs以及不同疾病调控的报道。
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