B淋巴细胞成熟存在缺陷的小鼠无法对免疫原性载体上的磷酸胆碱产生反应。
Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.
作者信息
Mond J J, Lieberman R, Inman J K, Mosier D E, Paul W E
出版信息
J Exp Med. 1977 Oct 1;146(4):1138-42. doi: 10.1084/jem.146.4.1138.
Abstract
Mice with the CBA/N defect are unresponsive to the hapten phosphorylcholine (PC) even when presented on a variety of immunogenic carriers. Since these mice have the variable region gene for PC, their inability to respond may reflect deletion or suppression of the line of B lymphocytes which is responsible for the anti-PC response.
摘要
具有CBA/N缺陷的小鼠即使在多种免疫原性载体上呈现半抗原磷酸胆碱（PC）时，也对半抗原无反应。由于这些小鼠具有针对PC的可变区基因，它们无反应的能力可能反映了负责抗PC反应的B淋巴细胞系的缺失或抑制。
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