Mond J J, Lieberman R, Inman J K, Mosier D E, Paul W E
J Exp Med. 1977 Oct 1;146(4):1138-42. doi: 10.1084/jem.146.4.1138.
Mice with the CBA/N defect are unresponsive to the hapten phosphorylcholine (PC) even when presented on a variety of immunogenic carriers. Since these mice have the variable region gene for PC, their inability to respond may reflect deletion or suppression of the line of B lymphocytes which is responsible for the anti-PC response.
具有CBA/N缺陷的小鼠即使在多种免疫原性载体上呈现半抗原磷酸胆碱(PC)时,也对半抗原无反应。由于这些小鼠具有针对PC的可变区基因,它们无反应的能力可能反映了负责抗PC反应的B淋巴细胞系的缺失或抑制。