在对同一半抗原产生抗体存在X连锁缺陷的小鼠中的磷酸胆碱特异性辅助性T细胞。
Phosphorylcholine-specific helper T cells in mice with an X-linked defect of antibody production to the same hapten.
作者信息
Kaplan R B, Quintáns J
出版信息
J Exp Med. 1979 Jan 1;149(1):267-72. doi: 10.1084/jem.149.1.267.
Abstract
F1 male mice with the CBA/N X-linked defect that are unable to produce plaque-forming cell responses to phosphorylcholine (PC) provide normal PC-specific helper T-cell activity when compared to F1 female littermates. Inhibition of helper activity with anti-idiotypic antiserum indicates that PC-specific T cells from both NBF1 female and male mice possess predominantly BALB/c myeloma protein HOPC-8 idiotypic determinants. Therefore, the CBA/N defect cannot be explained as a deletion of genes coding for V-region anti-PC specificities. The demonstration of helper activity in NBF1 male mice, which occurs in the absence of anti-PC antibody synthesis, also demonstrates the endogenous origin of the T-cell receptor.
摘要
具有CBA/N X连锁缺陷的F1雄性小鼠不能对磷酸胆碱（PC）产生噬斑形成细胞反应，与同窝F1雌性小鼠相比，其提供正常的PC特异性辅助性T细胞活性。用抗独特型抗血清抑制辅助活性表明，来自NBF1雌性和雄性小鼠的PC特异性T细胞主要具有BALB/c骨髓瘤蛋白HOPC-8独特型决定簇。因此，CBA/N缺陷不能解释为编码V区抗PC特异性的基因缺失。在不合成抗PC抗体的情况下，NBF1雄性小鼠中辅助活性的证明也证明了T细胞受体的内源性起源。
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Phosphorylcholine-specific helper T cells in mice with an X-linked defect of antibody production to the same hapten.在对同一半抗原产生抗体存在X连锁缺陷的小鼠中的磷酸胆碱特异性辅助性T细胞。
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本文引用的文献
1
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2
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
3
Affinity labeling of a phosphorylcholine binding mouse myeloma protein.磷酸胆碱结合小鼠骨髓瘤蛋白的亲和标记
Biochemistry. 1972 Feb 29;11(5):766-71. doi: 10.1021/bi00755a014.
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J Immunol. 1968 Apr;100(4):744-51.
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Cell Immunol. 1978 Jul;38(2):294-301. doi: 10.1016/0008-8749(78)90060-6.
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