Chakraborty Debjit, Rangamani Sukanya, Kulothungan Vaitheeswaran, Chaturvedi Meesha, Stephen S, Das Priyanka, Sudarshan Kondalli Lakshminarayana, Janani Surya R, Sathish Kumar K, John Anish, Manoharan N, Koyande S S, Swaminathan Rajaraman, Ramesh C, Shrivastava Atul, Ganesh B, Mathur Prashant, Nandakumar Ambakumar
National Centre for Disease Informatics and Research (NCDIR), Indian Council of Medical Research (ICMR), Bengaluru, India.
Population Based Cancer Registry, Institute of Rotary Cancer Hospital and All India Institute of Medical Sciences, New Delhi, India.
J Bone Oncol. 2018 May 17;12:49-53. doi: 10.1016/j.jbo.2018.04.002. eCollection 2018 Sep.
Ewing sarcoma is a malignant tumour found mainly in childhood and adolescence. The present study aims at analyzing the data on Ewing sarcoma cases of bone from the National Cancer Registry Programme, India to provide incidence, patterns, and trends in the Indian population.
The data of five Population Based Cancer Registries (PBCR) of Bangalore, Mumbai, Chennai, Bhopal and Delhi over 30 years period (1982- 2011) were used to calculate the Age Specific and Age Standardized Incidence Rates (ASpR and ASIR), and trends in incidence was analyzed by linear and Joinpoint Regression.
Ewing sarcoma comprised around 15 % of all bone malignancies. Sixty-eight percent were 0-19 years, with 1.6 times risk of tumour in bones of limbs as compared to other bones. The highest incidence rate (per million) was in the 10-14 years age group (male -4.4, female -2.9) with significantly increasing trend in ASpR observed in both sexes. Pooled ASIR per million for all ages was higher in male (1.6) than female (1.0) with an increasing rate ratio of ASIR with increase in age. Trend of pooled ASIR for all ages was significantly increased in both sexes. Twelve percent cases were reported in ≥30 years of age.
This paper has described population based measurements on burden and trends in incidence of skeletal Ewing in India. These may steer further research questions on the clinical and molecular epidemiology to explain factors associated with the increasing incidence of Ewing sarcoma bone observed in India.
尤因肉瘤是一种主要发生于儿童和青少年时期的恶性肿瘤。本研究旨在分析来自印度国家癌症登记计划的骨尤因肉瘤病例数据，以提供印度人群中的发病率、模式及趋势。
使用班加罗尔、孟买、金奈、博帕尔和德里五个基于人群的癌症登记处（PBCR）30年期间（1982 - 2011年）的数据来计算年龄特异性和年龄标准化发病率（ASpR和ASIR），并通过线性和连接点回归分析发病率趋势。
尤因肉瘤约占所有骨恶性肿瘤的15%。68%的病例为0 - 19岁，四肢骨发生肿瘤的风险是其他骨骼的1.6倍。发病率最高（每百万）的是10 - 14岁年龄组（男性 - 4.4，女性 - 2.9），两性的年龄特异性发病率均呈现显著上升趋势。各年龄段每百万合并年龄标准化发病率男性（1.6）高于女性（1.0），且年龄标准化发病率的增长率随年龄增加而上升。所有年龄段合并年龄标准化发病率在两性中均显著上升。12%的病例报告年龄≥30岁。
本文描述了基于人群的印度骨骼尤因肉瘤负担及发病率趋势的测量结果。这些结果可能为临床和分子流行病学的进一步研究问题提供方向，以解释印度观察到的骨尤因肉瘤发病率上升的相关因素。
