Majerus P W, Connolly T M, Deckmyn H, Ross T S, Bross T E, Ishii H, Bansal V S, Wilson D B
Science. 1986 Dec 19;234(4783):1519-26. doi: 10.1126/science.3024320.
The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular agonists. The phosphoinositides break down to liberate messenger molecules or precursors of messenger molecules. Many different compounds are formed, although the functions of only a few are understood. Recent studies elaborating the pathways for formation of products from phosphoinositides and the factors controlling their metabolism are summarized here.
磷酸肌醇是存在于所有真核细胞中的微量磷脂。它们是信使分子的储存形式，这些信使分子可跨细胞膜传递信号并引发对细胞外激动剂的反应。磷酸肌醇分解以释放信使分子或信使分子的前体。虽然仅了解少数几种化合物的功能，但会形成许多不同的化合物。本文总结了阐述磷酸肌醇产物形成途径及其代谢控制因素的最新研究。
