Department of Dermatology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Department of Dermatology, The Third Affiliated Hospital, Qiqihar Medical College, Qiqihar 161000, China.
Biomed Res Int. 2018 Aug 29;2018:2372895. doi: 10.1155/2018/2372895. eCollection 2018.
The antitumor effects of Huaier have been recently revealed. However, no research has been conducted on the effects of Huaier on keratinocyte proliferation and for the treatment of psoriasis. Hacat cells were treated with different concentrations of Huaier for different periods of times. The effects on cell proliferation and vitality and on the cell cycle were detected. Patients with mild-to-moderate psoriasis were randomized and divided into two groups in a double-blind manner. The experimental group was given sugar-free Yinxie granules and Huaiqihuang (HQH) granules, and the control group was given sugar-free Yinxie granules and placebo. After 4 weeks, various therapeutic indexes were compared. Huaier significantly inhibited Hacat cell proliferation, suppressed vitality, and blocked the cell cycle in the G1 phase compared with the control group (P < 0.01, respectively). After treatment for 4 weeks, the number of patients between the two groups that experienced a 50% reduction in the Psoriasis Area and Severity Index (PASI 50), PASI 75 and PASI 90, was significantly different (P <0.01). The body surface area (BSA) affected by psoriasis and static physician's global assessment (sPGA) was significantly reduced (P < 0.01); additionally, a significant improvement in the Dermatology Life Quality Index (DLQI) (P < 0.01) was observed. Huaier has shown promising effects in both clinical and experimental setting in this preliminary study and it might provide some benefit in the treatment of psoriasis vulgaris in the future.
白花蛇舌草的抗肿瘤作用最近被揭示出来。然而，尚未有研究探讨白花蛇舌草对角质形成细胞增殖的影响及其在银屑病治疗中的作用。我们用不同浓度的白花蛇舌草处理不同时间的 Hacat 细胞，检测其对细胞增殖和活力以及细胞周期的影响。将轻度至中度银屑病患者随机分为两组，进行双盲分组。实验组给予无糖银屑颗粒和槐芪黄（HQH）颗粒，对照组给予无糖银屑颗粒和安慰剂。4 周后，比较各种治疗指标。与对照组相比，白花蛇舌草明显抑制 Hacat 细胞增殖，抑制活力，并阻断细胞周期进入 G1 期（P < 0.01）。治疗 4 周后，两组患者中 PASI50、PASI75 和 PASI90 减少 50%的患者数量差异有统计学意义（P < 0.01）。银屑病受累体表面积（BSA）和静态医师整体评估（sPGA）明显减少（P < 0.01）；此外，皮肤病生活质量指数（DLQI）也明显改善（P < 0.01）。在这项初步研究中，白花蛇舌草在临床和实验研究中均显示出良好的效果，未来可能对寻常型银屑病的治疗有一定益处。
