Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Ann Palliat Med. 2020 Mar;9(2):182-189. doi: 10.21037/apm.2020.02.07. Epub 2020 Mar 2.
Non-alcoholic fatty liver disease (NAFLD) is a risk factor for carotid plaque in the general population; however, whether NAFLD is associated with carotid plaque in aged population remains unknown. This cross-sectional study was conducted to evaluate the association between NAFLD and carotid plaque in a Chinese aged population.
A total number of 12,990 Chinese aged adults (7,685 men and 5,305 women) were included. NAFLD was diagnosed based on the recommendation of Asia-Pacific Working Party on NAFLD and Chinese Association for the Study of Liver Disease and excessive alcohol consumption (weekly alcohol consumption ≤210 g in men and ≤140 g in women) was excluded. Carotid plaque was confirmed by ultrasonography. Potential confounders and biochemical findings were collected at baseline. Logistic regression model was employed to evaluate the association between NAFLD and carotid plaque.
The prevalence of carotid plaque was significantly higher in aged participants with NAFLD than in those without NAFLD (22.4% vs. 16.3%, P<0.001). NAFLD is associated with carotid plaque [odd ratio (OR) =1.89, 95% confidence interval (CI): 1.59-2.24], after adjusting for age, gender, BMI, liver and kidney function, glucose level, lipid profiles, and white blood cell (WBC) count. The association between NAFLD and carotid plaque was attenuated when participants with elevated ALT (≥75 IU/L), a history of cardiovascular diseases (CVDs) and obesity were censored although the significant association remained.
NAFLD is associated with carotid plaque in Chinese aged population.
非酒精性脂肪性肝病（NAFLD）是普通人群颈动脉斑块的一个危险因素；然而，NAFLD 是否与老年人群的颈动脉斑块有关尚不清楚。本横断面研究旨在评估中国老年人群中 NAFLD 与颈动脉斑块之间的关系。
共纳入 12990 名中国老年人（男性 7685 名，女性 5305 名）。根据亚太非酒精性脂肪性肝病工作组和中华肝脏病学会的建议诊断为 NAFLD，并排除了过量饮酒（男性每周饮酒量≤210g，女性每周饮酒量≤140g）。通过超声检查确认颈动脉斑块。在基线时收集了潜在的混杂因素和生化发现。采用 logistic 回归模型评估 NAFLD 与颈动脉斑块之间的关系。
患有 NAFLD 的老年参与者颈动脉斑块的患病率明显高于无 NAFLD 的参与者（22.4% vs. 16.3%，P<0.001）。NAFLD 与颈动脉斑块相关[比值比（OR）=1.89，95%置信区间（CI）：1.59-2.24]，调整年龄、性别、BMI、肝肾功能、血糖水平、血脂谱和白细胞（WBC）计数后。当排除 ALT 升高（≥75IU/L）、心血管疾病（CVDs）病史和肥胖的参与者后，NAFLD 与颈动脉斑块之间的关联减弱，但仍具有显著相关性。
NAFLD 与中国老年人群的颈动脉斑块有关。
