左旋甲状腺素对绵羊血清血管紧张素转换酶活性的影响。

Effect of L-thyroxine on serum angiotensin converting enzyme activity in sheep.

作者信息

Verma P, Noble S, Miller R

出版信息

Clin Exp Pharmacol Physiol. 1986 Aug;13(8):609-12. doi: 10.1111/j.1440-1681.1986.tb00945.x.

DOI:10.1111/j.1440-1681.1986.tb00945.x

Abstract

The effect of L-thyroxine on serum angiotensin converting enzyme activity using a sheep model was examined. Following two weeks of L-thyroxine treatment, the activity of serum angiotensin converting enzyme was increased from 6.92 U/ml to 8.65 U/ml (s.e.m. = 0.40, n = 13, P less than 0.01). Discontinuation of L-thyroxine treatment resulted in lowering the activity of serum angiotensin converting enzyme within three weeks to values close to those observed during the control period. It was concluded that L-thyroxine modulates serum angiotensin converting enzyme activity. The sheep is an appropriate animal model for the study of the factors that control serum angiotensin converting enzyme activity.

摘要

使用绵羊模型研究了L-甲状腺素对血清血管紧张素转换酶活性的影响。L-甲状腺素治疗两周后，血清血管紧张素转换酶活性从6.92 U/ml升高至8.65 U/ml（标准误=0.40，n=13，P<0.01）。停止L-甲状腺素治疗导致血清血管紧张素转换酶活性在三周内降至接近对照期观察到的值。得出结论，L-甲状腺素可调节血清血管紧张素转换酶活性。绵羊是研究控制血清血管紧张素转换酶活性因素的合适动物模型。