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个性化医疗:从希望到实践的奥德赛之旅。

Personalised Medicine: The Odyssey from Hope to Practice.

作者信息

Visvikis-Siest Sophie, Gorenjak Vesna, Stathopoulou Maria G

机构信息

Inserm, IGE-PCV, Université de Lorraine, 54000 Nancy, France.

Department of Internal Medicine and Geriatrics, CHU Technopôle Nancy-Brabois, Rue du Morvan, F-54511 Vandoeuvre-lès-Nancy, France.

出版信息

J Pers Med. 2018 Sep 21;8(4):31. doi: 10.3390/jpm8040031.

Abstract

In this endeavour, inspired by the Odyssey, we aim to embark with the reader on a journey on a ship from Troy to Ithaca, coursing through the history of the momentous events and achievements that paved the way for personalised medicine. We will set sail amidst important genetic discoveries, beginning with the discovery of the first human genome, and voyage through the projects that contributed to the progress of pharmacogenomic studies. Concurrently, we will propose methods to overcome the obstacles that are slowing the potential full implementation of accumulated knowledge into everyday practice. This journey aims to reflect on the frontiers of current genetic knowledge and the practical use of this knowledge in preventive, diagnostic and pharmacogenomic approaches to directly impact the socio-economic aspects of public health.

摘要

在这项受《奥德赛》启发的事业中,我们旨在与读者一同踏上从特洛伊到伊萨卡的航海之旅,追寻那些为个性化医疗铺平道路的重大事件和成就的历史轨迹。我们将从首次发现人类基因组这一重要的基因发现启航,穿梭于推动药物基因组学研究进展的各个项目之中。与此同时,我们将提出方法,以克服那些阻碍将积累的知识充分应用于日常实践的障碍。这次旅程旨在思考当前基因知识的前沿领域,以及这些知识在预防、诊断和药物基因组学方法中的实际应用,从而直接影响公共卫生的社会经济层面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d46/6313378/985f85eff0c1/jpm-08-00031-g001.jpg

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