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界定精准健康:一项范围综述方案

Defining precision health: a scoping review protocol.

作者信息

Ryan Jillian C, Viana John Noel, Sellak Hamza, Gondalia Shakuntla, O'Callaghan Nathan

机构信息

Precision Health Future Science Platform, Commonwealth Scientific and Industrial Research Organisation, Adelaide, South Australia, Australia

Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Adelaide, South Australia, Australia.

出版信息

BMJ Open. 2021 Feb 16;11(2):e044663. doi: 10.1136/bmjopen-2020-044663.

Abstract

INTRODUCTION

Precision health is a nascent field of research that would benefit from clearer operationalisation and distinction from adjacent fields like precision medicine. This clarification is necessary to enable precision health science to tackle some of the most complex and significant health problems that are faced globally. There is a pressing need to examine the progress in human precision health research in the past 10 years and analyse this data to first, find similarities and determine discordances in how precision health is operationalised in the literature and second, identify gaps and future directions for precision health research.

METHODS AND ANALYSIS

To define precision health and map research in this field, a scoping review will be undertaken and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses - Scoping Review Extension guidelines. Systematic searches of scientific databases (Medline, Embase, Scopus, Web of Science and PsycINFO) and grey literature sources (Google Scholar, Google Patents) identified 8053 potentially eligible articles published from 1 January 2010 to 30 June 2020. Following removal of duplicates, a total of 3190 articles were imported for screening. Article data will be extracted using a customised extraction template on Covidence and analysed descriptively using narrative synthesis.

ETHICS AND DISSEMINATION

Ethics approval is not required. Findings will be disseminated through professional networks, conference presentations and publication in a scientific journal.

摘要

引言

精准健康是一个新兴的研究领域,更清晰的操作化定义以及与精准医学等相邻领域的区分将使其受益。这种澄清对于使精准健康科学能够解决全球面临的一些最复杂和重大的健康问题是必要的。迫切需要审视过去10年人类精准健康研究的进展,并分析这些数据,首先是找出文献中精准健康操作化定义方面的异同,其次是确定精准健康研究的差距和未来方向。

方法与分析

为了定义精准健康并梳理该领域的研究情况,将根据系统评价与Meta分析优先报告条目——范围综述扩展指南进行一项范围综述并报告结果。对科学数据库(Medline、Embase、Scopus、Web of Science和PsycINFO)和灰色文献来源(谷歌学术、谷歌专利)进行系统检索,共识别出2010年1月1日至2020年6月30日发表的8053篇潜在符合条件的文章。去除重复项后,共导入3190篇文章进行筛选。文章数据将使用Covidence上的定制提取模板进行提取,并采用叙述性综合进行描述性分析。

伦理与传播

无需伦理批准。研究结果将通过专业网络、会议报告和在科学期刊上发表进行传播。

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