Li Ting, Deng Pengchi
College of Chemistry, Sichuan University, Chengdu, China.
Analytical & Testing Center, Sichuan University, Chengdu, China.
Genes Dis. 2016 Dec 13;4(1):28-36. doi: 10.1016/j.gendis.2016.12.001. eCollection 2017 Mar.
Cancer is one of the most serious diseases that cause an enormous number of deaths all over the world. Tumor metabolism has great discrimination from that of normal tissues. Exploring the tumor metabolism may be one of the best ways to find biomarkers for cancer detection, diagnosis and to provide novel insights into internal physiological state where subtle changes may happen in metabolite concentrations. Nuclear Magnetic Resonance (NMR) technique nowadays is a popular tool to analyze cell extracts, tissues and biological fluids, etc, since it is a relatively fast and an accurate technique to supply abundant biochemical information at molecular levels for tumor research. In this review, approaches in tumor metabolism are discussed, including sample collection, data profiling and multivariate data analysis methods etc. Some typical applications of NMR are also summarized in tumor metabolism.
癌症是导致全球大量死亡的最严重疾病之一。肿瘤代谢与正常组织的代谢有很大差异。探索肿瘤代谢可能是寻找癌症检测、诊断生物标志物以及深入了解内部生理状态（代谢物浓度可能发生细微变化）的最佳方法之一。如今，核磁共振（NMR）技术是分析细胞提取物、组织和生物体液等的常用工具，因为它是一种相对快速且准确的技术，能够在分子水平为肿瘤研究提供丰富的生化信息。在本综述中，讨论了肿瘤代谢的方法，包括样本采集、数据剖析和多变量数据分析方法等。还总结了NMR在肿瘤代谢中的一些典型应用。
