Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institute, Stockholm, Sweden.
Eur J Neurol. 2024 Dec;31(12):e16436. doi: 10.1111/ene.16436. Epub 2024 Aug 12.
This study evaluated associations of brain amyloid with 2-year objective and subjective cognitive measures in a trial-ready older general population at risk for dementia.
Forty-eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent C-Pittsburgh compound B (PiB) positron emission tomography (PET) scans and assessment of cognition (modified Neuropsychological Test Battery [NTB]) and subjective memory complaints (Prospective and Retrospective Memory Questionnaire).
Mean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB-PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable 2-year NTB total score and memory trajectories, but not with other objective or subjective cognitive measures. Overall, there was little cognitive decline during 2 years.
Amyloid accumulation may affect objective but not necessarily subjective cognition from a very early at-risk stage, although substantial decline likely requires >2 years to occur.
本研究旨在评估在痴呆风险较高的、适合进行临床试验的老年普通人群中，脑淀粉样蛋白与 2 年客观和主观认知测量的相关性。
芬兰老年干预研究以预防认知障碍和残疾项目的 48 名参与者接受了 C-Pittsburgh 复合 B（PiB）正电子发射断层扫描（PET）扫描，并进行了认知评估（改良神经心理测试电池[NTB]）和主观记忆主诉（前瞻性和回顾性记忆问卷）。
平均年龄为 71.4±5.06 岁，20 名参与者（42%）基线 PiB-PET 扫描阳性。淀粉样蛋白阳性与基线时 NTB 执行功能较低以及 2 年 NTB 总分和记忆轨迹较差相关，但与其他客观或主观认知测量无关。总的来说，在 2 年内认知衰退程度较小。
淀粉样蛋白积累可能会在早期高风险阶段影响客观认知，但不一定会影响主观认知，尽管发生明显衰退可能需要>2 年的时间。
