Department of Dermatology, University Hospital, Brest, France.
Acta Derm Venereol. 2019 Mar 1;99(3):279-283. doi: 10.2340/00015555-3053.
The objective of this study was to explore characteristics of pruritus in atopic dermatitis (AD) in relation to the severity of AD. A web-questionnaire was used, which included the Patient-Oriented SCORing Atopic Dermatitis index, the 5-D itch scale and the Brest questionnaire. A total of 170 participants were included (86.5% women, mean age 30.9 years). Severity of AD was mild for 8.2% of patients, moderate for 38.2% and severe for 53.5%. Mean 5-D itch scale was 13.2. The mean intensity of pruritus was 5.8, and mean sleep loss was 4.7 (from 0 to 10). The participants frequently described burning (61.8%) and stinging (58.8%); these symptoms suggest a neuropathic component. Pruritus was worse in severe AD compared with moderate AD, exhibiting a higher impact on sleep and more associated symptoms. The majority of participants reported sleep disturbance as a result of pruritus. The characteristics of pruritus varied depending on the severity of AD.
本研究旨在探讨特应性皮炎（AD）瘙痒的特征与 AD 严重程度的关系。采用网络问卷调查，包括患者导向的特应性皮炎评分（PO-SCORAD）、5-D 瘙痒量表和 Brest 问卷。共纳入 170 名参与者（86.5%为女性，平均年龄 30.9 岁）。8.2%的患者 AD 严重程度为轻度，38.2%为中度，53.5%为重度。5-D 瘙痒量表的平均评分为 13.2。瘙痒平均强度为 5.8，平均睡眠损失为 4.7（从 0 到 10）。参与者经常描述烧灼感（61.8%）和刺痛感（58.8%）；这些症状提示存在神经病理性成分。与中度 AD 相比，重度 AD 的瘙痒更严重，对睡眠和更多相关症状的影响更大。大多数参与者报告说瘙痒导致睡眠障碍。瘙痒的特征因 AD 的严重程度而异。
