Bai Jigang, Huo Xiongwei, Ma Jia, Lv Yi, Yan Xiaopeng
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Regenerative Medicine and Surgery Engineering Research Center of Shaanxi Province, Xi'an, China.
Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
J Surg Res. 2018 Nov;231:24-29. doi: 10.1016/j.jss.2018.05.006. Epub 2018 May 30.
Magnetic compression technique (MCT) is useful for construction of digestive tract anastomoses in pigs and dogs. This study determined the efficacy of MCT for performing colonic anastomosis in rats.
Twenty male Sprague-Dawley rats (230-280 g) were randomly apportioned to a study group that underwent colonic anastomosis with MCT or a control group subjected to hand-sewn colonic anastomosis. The groups were compared for time to construct the anastomosis, survival rate, and postoperative complications. Animals were euthanized at 1 mo postsurgery to study the burst pressure and histology of the anastomoses.
The study group required significantly less time to construct the anastomosis (6.50 ± 1.58 min) than did the control (15.6 ± 2.22 min). The survival rate of the study group (100%) was significantly higher than that of the control group (60%). In the control group, three rats developed anastomotic leakage and one rat developed anastomotic obstruction. No anastomotic leakage or obstruction was observed in the study group. The burst pressures of the two groups were similar. Histology showed that the study group had better alignment of the tissue layers and less inflammation compared with the control group.
MCT is a safe and feasible technique for colonic anastomosis in rats, with better postoperative outcomes compared with hand-sewn anastomosis.
磁压缩技术（MCT）在猪和狗的消化道吻合术中很有用。本研究确定了MCT在大鼠结肠吻合术中的疗效。
将20只雄性Sprague-Dawley大鼠（230 - 280克）随机分为接受MCT结肠吻合术的研究组或接受手工缝合结肠吻合术的对照组。比较两组吻合口构建时间、生存率和术后并发症。术后1个月对动物实施安乐死，以研究吻合口的破裂压力和组织学情况。
研究组构建吻合口所需时间（6.50±1.58分钟）明显少于对照组（15.6±2.22分钟）。研究组的生存率（100%）显著高于对照组（60%）。对照组有3只大鼠发生吻合口漏，1只大鼠发生吻合口梗阻。研究组未观察到吻合口漏或梗阻。两组的破裂压力相似。组织学显示，与对照组相比，研究组组织层排列更好，炎症更少。
MCT是一种用于大鼠结肠吻合术的安全可行技术，与手工缝合吻合术相比，术后效果更好。
