National Institute for Medical Research, Tanga Centre, Tanga, Tanzania.
Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Trop Med Int Health. 2018 Nov;23(11):1176-1187. doi: 10.1111/tmi.13149. Epub 2018 Oct 2.
To determine risk factors of pre-hypertension and hypertension in a cohort of 1247 rural Tanzanian women before conception.
Demographic and socioeconomic data, anthropometric measurements, past medical and obstetric history and other risk factors for pre-hypertension and hypertension were collected using a structured questionnaire. Multiple logistic regression analysis was used to evaluate the associations between anthropometric indices and other risk factors of pre-hypertension and hypertension. The predictive power of different anthropometric indicators for identification of pre-hypertension and hypertension patients was determined by Receiver Operating Characteristic curves (ROC).
The median (range) age was 28.0 (18-40) years. The age-standardised prevalences of pre-hypertension and hypertension were 37.2 (95% CI 34.0-40.6) and 8.5% (95%CI 6.7-10.8), respectively. Of hypertensive patients (n = 98), only 20 (20.4%) were aware of their condition. In multivariate analysis, increasing age, obesity and haemoglobin levels were significantly associated with pre-hypertension and hypertension.
Despite a low prevalence of hypertension, over one third of the women had pre-hypertension. This poses a great challenge ahead as pre-hypertensive women may progress into hypertension as they grow older without appropriate interventions. Obesity was the single most important modifiable risk factor for pre-hypertension and hypertension.
在坦桑尼亚农村的 1247 名孕妇队列中,确定妊娠前高血压前期和高血压的危险因素。
使用结构化问卷收集人口统计学和社会经济学数据、人体测量学测量值、既往病史和其他高血压前期和高血压的危险因素。采用多因素逻辑回归分析评估人体测量指数与高血压前期和高血压其他危险因素之间的关系。通过接收者操作特征曲线(ROC)确定不同人体测量指标对高血压前期和高血压患者的识别能力。
中位数(范围)年龄为 28.0 岁(18-40 岁)。年龄标准化的高血压前期和高血压患病率分别为 37.2%(95%置信区间为 34.0-40.6)和 8.5%(95%置信区间为 6.7-10.8)。在高血压患者中(n=98),只有 20 人(20.4%)知道自己的病情。多因素分析显示,年龄增长、肥胖和血红蛋白水平与高血压前期和高血压显著相关。
尽管高血压患病率较低,但超过三分之一的女性患有高血压前期。由于没有适当的干预措施,随着年龄的增长,这些高血压前期女性可能会发展为高血压,因此这是一个巨大的挑战。肥胖是高血压前期和高血压的唯一最重要的可改变危险因素。