Instituto de Química de São Carlos , Universidade de São Paulo , CP 780 , CEP 13560-970 , São Carlos , SP , Brazil.
Brazilian Biosciences National Laboratory , National Center for Research in Energy and Material , Giuseppe Maximo Scolfaro, 10000, Pólo II de Alta Tecnologia de Campinas , 13083-970 Campinas , SP , Brazil.
J Nat Prod. 2018 Oct 26;81(10):2296-2300. doi: 10.1021/acs.jnatprod.8b00533. Epub 2018 Oct 3.
The new pyrrole-imidazole and pyrrole-guanidine alkaloids 4-debromooroidin (1), 4-debromougibohlin (2), 5-debromougibohlin (3), and 5-bromopalau'amine (4), along with the known hymenidin (5) and (+)-monobromoisophakellin (6), have been isolated from a Dictyonella sp. marine sponge, collected at the Amazon River mouth. The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this series.
从亚马逊河口采集的 Dictyonella sp. 海洋海绵中分离得到了新的吡咯并咪唑和吡咯胍生物碱 4-脱溴奥里丁（1）、4-脱溴乌比谷滨（2）、5-脱溴乌比谷滨（3）和 5-溴巴劳胺（4），以及已知的 hymenidin（5）和（+）-单溴异菲克林（6）。在从海洋海绵中分离得到的溴代吡咯生物碱中，化合物 1、2 和 4 的溴取代模式是不寻常的。记录了化合物 1-6 对 20S 蛋白酶体的抑制活性，其中 5-溴巴劳胺（4）在该系列中活性最强。
