McCall Buckley, McPartland Connor K, Moore Reece, Frank-Kamenetskii Anastasia, Booth Brian W
Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
Antioxidants (Basel). 2018 Oct 4;7(10):135. doi: 10.3390/antiox7100135.
Astaxanthin (ASX) is a marine-based ketocarotenoid; an accessory pigment in plants in that it has many different potential functions. ASX is an antioxidant that is notably more potent than many other antioxidants. Antioxidants have anti-inflammatory and oxidative stress-reducing properties to potentially reduce the incidence of cancer or inhibit the expansion of tumor cells. In this study, we tested the hypothesis that ASX would inhibit proliferation and migration of breast cancer cells in vitro. We found that application of ASX significantly reduced proliferation rates and inhibited breast cancer cell migration compared to control normal breast epithelial cells. Based on these results, further investigation of the effects of ASX on not only breast cancer cells, but other forms of tumor cells, should be carried out.
虾青素（ASX）是一种海洋来源的酮类胡萝卜素；作为植物中的辅助色素，它具有许多不同的潜在功能。ASX是一种抗氧化剂，其抗氧化能力明显强于许多其他抗氧化剂。抗氧化剂具有抗炎和减轻氧化应激的特性，有可能降低癌症发病率或抑制肿瘤细胞的增殖。在本研究中，我们检验了ASX会在体外抑制乳腺癌细胞增殖和迁移的假设。我们发现，与对照正常乳腺上皮细胞相比，应用ASX可显著降低增殖率并抑制乳腺癌细胞迁移。基于这些结果，应该进一步研究ASX不仅对乳腺癌细胞，而且对其他形式肿瘤细胞的影响。
