Center for Epigenetics and Metabolism, Department of Biological Chemistry, INSERM U1233, School of Medicine, University of California, Irvine, USA.
Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, 3000, Australia.
Mol Metab. 2018 Oct;16:1-11. doi: 10.1016/j.molmet.2018.06.008. Epub 2018 Jun 18.
Advances in the field of metabolomics and the concomitant development of bioinformatics tools constitute a promising avenue towards the development of precision medicine and personalized profiling for numerous disease states. Studies in animal models have strengthened this concept, but the application in human subjects is scarce.
Utilizing high-throughput metabolomics, we have analyzed the metabolome levels of human serum and skeletal muscle in the morning and evening in response to divergent nutritional challenges in order to identify unique signatures present in serum and muscle.
We reveal dynamic daily variation of human metabolome unique to serum and muscle. The overall effect of nutritional challenges on the serum and muscle metabolome results in a profound rewiring of morning-evening metabolic profiles in human participants in response to the timing and type of dietary challenge.
We highlight time-of-day and meal-composition dependence of reprogramming of human metabolome by nutritional challenges.
代谢组学领域的进展和随之发展的生物信息学工具为精准医学和众多疾病状态的个性化分析提供了有前景的途径。动物模型的研究加强了这一概念，但在人体中的应用却很少。
我们利用高通量代谢组学分析了人类血清和骨骼肌在早晚对不同营养挑战的代谢组水平，以确定血清和肌肉中存在的独特特征。
我们揭示了人类血清和肌肉代谢组的动态日变化，这种变化是独特的。营养挑战对血清和肌肉代谢组的整体影响导致人类参与者的晨-晚代谢特征发生深刻的重编，以响应饮食挑战的时间和类型。
我们强调了营养挑战对人类代谢组重编程的时间和膳食成分依赖性。
