Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):382-393. doi: 10.1016/j.bbagrm.2018.09.010. Epub 2018 Oct 5.
Cellular function relies on multiple pathways that are coordinated to ensure the proper execution of gene expression networks. Failure to coordinate the multiple programs active in the cell can have catastrophic consequences and lead to diseases such as cancer. At the post-transcriptional level, RNA modifications play important roles in the regulation of gene expression. N6-methyladenosine (mA) is the most abundant internal messenger RNA (mRNA) modification and has gained increasing interest in the last few years as a dynamic regulator of RNA metabolism. Modifications regulate all stages of the RNA life cycle, from transcription to decay. Recent studies have pointed to the role of RNA methylation in cancer initiation and progression, and aberrant modification has served as a biomarker of early-stage diagnosis in several cancers. Here, we review the regulation of mA, disruptions to methylation-dependent pathways that influence carcinogenesis, and potential avenues for mA-related therapeutic strategies.
细胞功能依赖于多个途径，这些途径需要协调一致，以确保基因表达网络的正常执行。如果不能协调细胞中活跃的多种程序，可能会产生灾难性的后果，并导致癌症等疾病。在转录后水平上，RNA 修饰在基因表达调控中发挥着重要作用。N6-甲基腺苷 (mA) 是最丰富的内部信使 RNA (mRNA) 修饰，近年来作为 RNA 代谢的动态调节剂引起了越来越多的关注。修饰调节 RNA 生命周期的所有阶段，从转录到降解。最近的研究指出了 RNA 甲基化在癌症发生和发展中的作用，并且异常修饰已成为几种癌症早期诊断的生物标志物。在这里，我们回顾了 mA 的调控、影响致癌作用的甲基化依赖性途径的破坏以及与 mA 相关的治疗策略的潜在途径。
