Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut D'Investigació Sanitària Pere Virgili, Universitat Rovira I Virgili, Reus, Spain.
Department of Radiation Oncology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira I Virgili, Reus, Spain.
Breast. 2018 Dec;42:142-149. doi: 10.1016/j.breast.2018.09.005. Epub 2018 Oct 1.
Alterations in the circulating levels of trace elements have been observed in breast cancer (BC) patients. However, the relationships between these alterations and the metabolic and clinical consequences of BC are unknown. The treatment-of-choice of BC is surgery followed by radiation therapy (RT). The present study was aimed at investigating: 1) the concentrations of several trace elements in BC patients, and their relationships with the intrinsic molecular subtypes of tumors; 2) the toxicological effect of RT. We studied 49 women with BC who were scheduled to receive RT following excision of the tumor. Plasma samples were obtained before and after the irradiation procedure. The control group was composed of 49 healthy women. Patients had significantly lower pre-RT concentrations of B, Cu, and Zn, and significantly higher concentrations of Sr than the control group. Irradiation was associated with a striking increase in plasma B concentrations, while Cu, Fe, Sr and Zn concentrations were not significantly different from pre-RT levels, albeit Sr and Zn showed non-significant trends towards increases. The plasma concentrations of B, Cu, Fe, Sr, and Zn were associated with the tumor expression of hormone receptors, epidermal growth factor receptor 2, Ki67 antigen, as well as dermatitis and asthenia, all of which represent the main toxicological responses to RT.
在乳腺癌 (BC) 患者中观察到微量元素循环水平的改变。然而，这些改变与 BC 的代谢和临床后果之间的关系尚不清楚。BC 的治疗选择是手术加放射治疗 (RT)。本研究旨在研究：1) BC 患者的几种微量元素浓度及其与肿瘤固有分子亚型的关系；2) RT 的毒理学效应。我们研究了 49 名计划在切除肿瘤后接受 RT 的 BC 女性患者。在照射程序前后获得血浆样本。对照组由 49 名健康女性组成。与对照组相比，患者在 RT 前的 B、Cu 和 Zn 浓度明显降低，Sr 浓度明显升高。辐照与血浆 B 浓度的显著增加有关，而 Cu、Fe、Sr 和 Zn 浓度与 RT 前水平无显著差异，尽管 Sr 和 Zn 呈非显著增加趋势。B、Cu、Fe、Sr 和 Zn 的血浆浓度与激素受体、表皮生长因子受体 2、Ki67 抗原的肿瘤表达以及皮炎和乏力有关，所有这些都代表了 RT 的主要毒理学反应。
