Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangdong Engineering Technology Research Center of Nutrition Translation, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
Nutrients. 2018 Oct 8;10(10):1457. doi: 10.3390/nu10101457.
A variety of dietary natural products have shown hepatoprotective effects. Increasing evidence has also demonstrated that gut microorganisms play an important role in the hepatoprotection contributed by natural products. Gut dysbiosis could increase permeability of the gut barrier, resulting in translocated bacteria and leaked gut-derived products, which can reach the liver through the portal vein and might lead to increased oxidative stress and inflammation, thereby threatening liver health. Targeting gut microbiota modulation represents a promising strategy for hepatoprotection. Many natural products could protect the liver from various injuries or mitigate hepatic disorders by reverting gut dysbiosis, improving intestinal permeability, altering the primary bile acid, and inhibiting hepatic fatty acid accumulation. The mechanisms underlying their beneficial effects also include reducing oxidative stress, suppressing inflammation, attenuating fibrosis, and decreasing apoptosis. This review discusses the hepatoprotective effects of dietary natural products via modulating the gut microbiota, mainly focusing on the mechanisms of action.
多种膳食天然产物已显示出保肝作用。越来越多的证据表明，肠道微生物在天然产物发挥的保肝作用中起着重要作用。肠道菌群失调会增加肠道屏障的通透性，导致移位细菌和漏出的肠道来源产物通过门静脉到达肝脏，并可能导致氧化应激和炎症增加，从而威胁肝脏健康。靶向调节肠道微生物群代表了一种有前途的保肝策略。许多天然产物可以通过逆转肠道菌群失调、改善肠道通透性、改变初级胆汁酸和抑制肝脏脂肪酸积累来保护肝脏免受各种损伤或减轻肝障碍。其有益作用的机制还包括降低氧化应激、抑制炎症、减轻纤维化和减少细胞凋亡。本文主要讨论了通过调节肠道微生物群发挥保肝作用的膳食天然产物，重点讨论了其作用机制。
