Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
J Sci Food Agric. 2019 Mar 30;99(5):2096-2107. doi: 10.1002/jsfa.9402. Epub 2018 Nov 12.
Limited studies have examined links between maternal methyl donor (MET) supplementation and the growth-development characteristics of offspring, and possible underlying mechanisms for such links. This study investigated the effect of maternal or post-weaning MET-supplementation on growth performance, carcass characteristics, and meat quality of the finishing (d 180) offspring. Twenty-four sows were placed on a control (C) or MET-supplemented diet during pregnancy and lactation. Forty-eight female offspring were fed the control or MET-supplemented diet from weaning to 6 months of age, resulting in four study groups (six litters per group): C/C, C/MET, MET/C, and MET/MET.
Maternal MET-supplementation increased average daily gain (ADG), body weight (BW), lean percentage and longissimus dorsi (LD) of the offspring at day 180 (P < 0.05), and upregulated the myosin heavy chain IIx, myogenic differentiation and muscle regulatory factor 4 mRNA levels in the LD muscle (P < 0.05). Meanwhile, offspring from maternal MET-supplementation exhibited a higher pH post mortem and superoxide dismutase activity, a lower L , glycolytic potential, malonaldehyde content in the LD muscle, and plasma homocysteine concentration (P < 0.05).
Maternal MET-supplementation has a remarkable effect on growth performance, carcass traits, and meat quality of the offspring, which is associated with increased expression levels of myogenic genes and anti-oxidant capacity. © 2018 Society of Chemical Industry.
有限的研究考察了母体甲基供体（MET）补充与后代生长发育特征之间的联系，以及这种联系的潜在机制。本研究调查了母体或断奶后 MET 补充对育肥（d180）后代生长性能、胴体特征和肉质的影响。24 头母猪在妊娠和哺乳期分别接受对照（C）或 MET 补充饮食。48 头雌性后代从断奶到 6 月龄接受对照或 MET 补充饮食，分为四组（每组 6 窝）：C/C、C/MET、MET/C 和 MET/MET。
母体 MET 补充增加了 180 日龄后代的平均日增重（ADG）、体重（BW）、瘦肉百分比和背最长肌（LD）（P<0.05），并上调了 LD 肌肉中的肌球蛋白重链 IIx、成肌分化和肌肉调节因子 4mRNA 水平（P<0.05）。同时，母体 MET 补充组的后代具有更高的宰后 pH 值和超氧化物歧化酶活性、更低的 L 、糖酵解潜能、LD 肌肉中的丙二醛含量和血浆同型半胱氨酸浓度（P<0.05）。
母体 MET 补充对后代的生长性能、胴体性状和肉质有显著影响，这与成肌基因表达水平的提高和抗氧化能力有关。 © 2018 化学工业协会。
