Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.
Curr Opin Chem Biol. 2019 Feb;48:19-25. doi: 10.1016/j.cbpa.2018.09.016. Epub 2018 Oct 9.
Mammalian cells are organized into different compartments that separate and facilitate physiological processes by providing specialized local environments and allowing different, otherwise incompatible biological processes to be carried out simultaneously. Proteins are targeted to these subcellular locations where they fulfill specialized, compartment-specific functions. Spatial proteomics aims to localize and quantify proteins within subcellular structures.
哺乳动物细胞组织成不同的隔室，通过提供专门的局部环境和允许不同的、否则不兼容的生物过程同时进行，从而分离和促进生理过程。蛋白质被靶向到这些亚细胞位置，在那里它们完成专门的、特定隔室的功能。空间蛋白质组学旨在定位和定量亚细胞结构内的蛋白质。
