The World of Protein Interactions: Defining the Caveolin 3 Cardiac Interactome.

Protein isoforms have highly similar amino acid sequences which can lead to similar biological roles. However in some cases, such as cell specific or enriched isoforms, they can assume distinct functions. This editorial discusses the work by Peper that defined the novel cardiac-interactome of caveolin 3 and the downstream functional consequences. Proteins live in a closely controlled communities where their complexes are highly regulated as are their location within a cell. There is a suite of ever-growing proteomic technologies capable of quantifying the chemical and biological diversity of the proteome including protein interactomes. This editorial discusses cutting-edge spatial proteomic technologies able to measure and define protein interactomes within living cells and precisely explore the immense landscape of the proteome.