未传代BK病毒转录控制区的结构与功能
Structure and function of the transcriptional control region of nonpassaged BK virus.
作者信息
Rubinstein R, Pare N, Harley E H
出版信息
J Virol. 1987 May;61(5):1747-50. doi: 10.1128/JVI.61.5.1747-1750.1987.
Abstract
We compared the nucleotide sequence in the transcriptional control region of BK virus isolates cloned directly from human urine (BK-WW) with that of prototype BK virus. BK-WW was found to have a 63-base-pair insertion and only one of the 68-base-pair enhancer repeat elements. In transient expression assays, BK-WW enhancer showed approximately one-half the activity given by the prototype enhancer.
摘要
我们将直接从人尿液中克隆的BK病毒分离株（BK-WW）转录控制区的核苷酸序列与原型BK病毒的进行了比较。发现BK-WW有一个63个碱基对的插入，且68个碱基对的增强子重复元件中只有一个。在瞬时表达试验中，BK-WW增强子的活性约为原型增强子的一半。
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