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基于杂二聚体肽的荧光-光声双模体内成像。

Dual-modal in vivo fluorescence and photoacoustic imaging using a heterodimeric peptide.

机构信息

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

出版信息

Chem Commun (Camb). 2018 Nov 22;54(94):13196-13199. doi: 10.1039/c8cc06774k.

DOI:10.1039/c8cc06774k
PMID:30334022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6357226/
Abstract

A heterodimeric peptide labeled with IRDye800 is used to perform dual-modal imaging of human esophageal xenograft tumors in vivo. Fluorescence and photoacoustic images provide complementary visualization of tumor dimensions in planar and sagittal views, respectively, demonstrating promise for targeted cancer diagnosis and staging.

摘要

一种标记有 IRDye800 的异二聚体肽被用于对人食管异种移植肿瘤进行体内双模成像。荧光和光声图像分别提供了肿瘤尺寸的平面和矢状视图的互补可视化，为靶向癌症诊断和分期提供了前景。

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J Med Chem. 2018 Jun 28;61(12):5323-5331. doi: 10.1021/acs.jmedchem.8b00405. Epub 2018 Jun 19.
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First-in-human intraoperative near-infrared fluorescence imaging of glioblastoma using cetuximab-IRDye800.使用西妥昔单抗-IR800 进行胶质母细胞瘤的首次人体术中近红外荧光成像。
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