Diaz Paola Monterroso, Jenkins Samir V, Alhallak Kinan, Semeniak Daria, Griffin Robert J, Dings Ruud P M, Rajaram Narasimhan
Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Division of Radiation Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Biomed Opt Express. 2018 Jul 24;9(8):3794-3804. doi: 10.1364/BOE.9.003794. eCollection 2018 Aug 1.
There is a critical need to identify patients with radiation-resistant tumors early after treatment commencement. In this study, we use diffuse reflectance spectroscopy (DRS) to investigate changes in vascular oxygenation and total hemoglobin concentration in A549 radiation-sensitive and resistant tumors treated with a clinically relevant dose fraction of 2 Gy. DRS spectra were acquired before, immediately after, 24, and 48 hours after radiation. Our data reveals a significantly higher reoxygenation (sO) in the radiation-resistant tumors 24 and 48h after treatment, and provides promising evidence that DRS can discern between the reoxygenation trends of radiation-sensitive and resistant tumors.
在治疗开始后尽早识别对放疗有抗性的肿瘤患者至关重要。在本研究中，我们使用漫反射光谱法（DRS）来研究接受2 Gy临床相关剂量分割治疗的A549放疗敏感和抗性肿瘤中血管氧合和总血红蛋白浓度的变化。在放疗前、放疗后即刻、放疗后24小时和48小时采集DRS光谱。我们的数据显示，放疗抗性肿瘤在治疗后24小时和48小时的再氧合（sO）显著更高，并提供了有前景的证据，表明DRS能够区分放疗敏感和抗性肿瘤的再氧合趋势。
