Zachow K R, Ostrow R S, Faras A J
Virology. 1987 May;158(1):251-4. doi: 10.1016/0042-6822(87)90263-7.
Human papillomavirus (HPV) type 5 is associated with benign and malignant lesions of the disease epidermodysplasia verruciformis (EV). Because of the strong correlation between the presence of HPV-5 and malignant progression in these patients, we have elucidated the nucleotide sequence of the HPV-5 genome. The size of the HPV-5 genome is 7746 nucleotides and its organization is similar to that of other papillomaviruses. The HPV-5 genome exhibits extensive sequence homology with another EV-associated papillomavirus, HPV-8, although HPV-5 appears to contain at least one additional open reading frame.
5型人乳头瘤病毒（HPV）与疣状表皮发育不良（EV）疾病的良性和恶性病变相关。由于HPV-5的存在与这些患者的恶性进展之间存在密切关联，我们已阐明了HPV-5基因组的核苷酸序列。HPV-5基因组的大小为7746个核苷酸，其结构与其他乳头瘤病毒相似。HPV-5基因组与另一种与EV相关的乳头瘤病毒HPV-8表现出广泛的序列同源性，尽管HPV-5似乎至少包含一个额外的开放阅读框。
