Eriksson A, Ahola H, Pettersson U, Moreno-Lopez J
Department of Veterinary Microbiology (Virology), Swedish University of Agriculture Sciences, Uppsala.
Virus Genes. 1988 Mar;1(2):123-33. doi: 10.1007/BF00555932.
The genome of the European elk papillomavirus (EEPV) was found to be 8,095 base pairs (bp) long and its genetic organization was similar to that of other papillomaviruses. Ten open reading frames (ORFs), designated E1-E7 and L1-L3, were identified in the genome, all located on one strand. The presence of the L3 ORF is rare among the papillomaviruses and to date has only been identified in the genomes of EEPV, the deer papillomavirus (DPV) and the Cottontail papillomavirus (CRPV). The ORF is well conserved between DPV and EEPV with regard to both length and sequence. Potential promoter regions were identified at the 5'-end of the E6 ORF, at the 3'-end of the E1 ORF and downstream of the L1 ORF. Furthermore, two potential polyadenylation signals were found, one located in the long control region (LCR), downstream of the L1 ORF, and another preceding the L2 ORF. The EEVP genome is closely related to the genome of the DPV, the most highly conserved regions being ORFs E1 (70%), E5 (69%), and L1 (74%).
欧洲驼鹿乳头瘤病毒（EEPV）的基因组长度为8095个碱基对（bp），其基因组织与其他乳头瘤病毒相似。在基因组中鉴定出10个开放阅读框（ORF），分别命名为E1 - E7和L1 - L3，均位于一条链上。L3 ORF在乳头瘤病毒中较为罕见，迄今为止仅在EEPV、鹿乳头瘤病毒（DPV）和棉尾兔乳头瘤病毒（CRPV）的基因组中被鉴定出来。该ORF在DPV和EEPV之间，在长度和序列方面都高度保守。在E6 ORF的5'端、E1 ORF的3'端以及L1 ORF的下游鉴定出潜在的启动子区域。此外，还发现了两个潜在的多腺苷酸化信号，一个位于长控制区（LCR），在L1 ORF的下游，另一个在L2 ORF之前。EEVP基因组与DPV的基因组密切相关, 最保守的区域是ORFs E1（70%）、E5（69%）和L1（74%）。
