Key Laboratory for Biomedical Engineering of Education Ministry of China, Zhejiang University, Hang Zhou, 310027, PR China; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110000, PR China.
Key Laboratory for Biomedical Engineering of Education Ministry of China, Zhejiang University, Hang Zhou, 310027, PR China.
Int J Biol Macromol. 2019 Jan;121:1160-1178. doi: 10.1016/j.ijbiomac.2018.10.076. Epub 2018 Oct 18.
Ganoderma, has been used for clinical applications for thousands of years as a highly-nutritious and significantly-effective medicinal herb. The active components and efficacy of Ganoderma are constantly being explored and supplemented every year. In recent years, more and more literature has reported the pharmacological effects of Ganoderma on anti-tumor, liver protection and immunity enhancement, especially on neuroprotection. Numerous research works on the neuroprotective effects of Ganoderma have been documented (e.g., modulation of neurogenesis, amelioration of Alzheimer's disease, therapeutic effect on epilepsy, the protective effect on neural cells in stroke injury, etc.) thus it has drawn increasing attention. However, an integrated and comprehensive review of recent research findings has not been detailed in any great depth. Therefore, the purpose of this review is to summarize and elucidate recent progress of neuroprotective effects of natural Ganoderma and its extracts.
灵芝，作为一种极具营养价值和显著功效的药用草本植物，已被临床应用数千年。灵芝的活性成分和功效每年都在不断被探索和补充。近年来，越来越多的文献报道了灵芝在抗肿瘤、肝脏保护和增强免疫力方面的药理作用，特别是在神经保护方面。大量研究工作证明了灵芝对神经保护的作用（例如，调节神经发生、改善阿尔茨海默病、对癫痫的治疗作用、对中风损伤中神经细胞的保护作用等），因此引起了越来越多的关注。然而，对最近研究结果的综合和全面综述并没有详细深入地描述。因此，本综述的目的是总结和阐明天然灵芝及其提取物的神经保护作用的最新进展。
