School for Advanced Research in Polymers (SARP)-Laboratory for Advanced Research in Polymeric Materials (LARPM), Central Institute of Plastics Engineering and Technology (CIPET), B-25, CNI Complex, Patia, Bhubaneswar, Odisha 751024, India.
School for Advanced Research in Polymers (SARP)-Laboratory for Advanced Research in Polymeric Materials (LARPM), Central Institute of Plastics Engineering and Technology (CIPET), B-25, CNI Complex, Patia, Bhubaneswar, Odisha 751024, India.
Int J Biol Macromol. 2019 Feb 1;122:137-148. doi: 10.1016/j.ijbiomac.2018.10.120. Epub 2018 Oct 18.
Currently, diabetes mellitus (DM) accelerated diabetic foot ulcer (DFU) remains vivacious health problem related with delayed healing and high amputation rates which leads to enormous clinical obligation. Keeping in view of the foregoing, researchers have been made in their efforts to develop novel materials which accelerate delayed wound healing in the diabetic patient and reduce the adversative influences of DFUs. The most prominent materials used for the wound healing application have biocompatibility, low cytotoxicity, excellent biodegradable properties, and antimicrobial activity properties. Utilization of nanoparticles has emerged as a protruding scientific and technological revolution in controlling DFUs. Biopolymers in combination with bioactive nanoparticles having antimicrobial, antibacterial, and anti-inflammatory properties have great potential in wound care to enhance the healing process of diabetic wound infectious. Combination of antibacterial nanoparticles like silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), copper nanoparticles (CuNPs) etc. with polymeric matrix could efficiently inhibit bacterial growth and at the same time fastens the healing process of a wound. This review briefed the recent development of different natural polymers and antibacterial nanoparticles to mitigate the diabetes mellitus based DFU.
目前，糖尿病加速的糖尿病足溃疡（DFU）仍然是一个与愈合延迟和高截肢率相关的严重健康问题，导致了巨大的临床负担。鉴于上述情况，研究人员一直在努力开发新型材料，以加速糖尿病患者的伤口愈合，并减少 DFU 的不利影响。用于伤口愈合应用的最突出的材料具有生物相容性、低细胞毒性、优异的可生物降解性和抗菌活性。纳米颗粒的利用已经成为控制 DFU 的突出的科学和技术革命。具有抗菌、抗细菌和抗炎特性的生物聚合物与生物活性纳米颗粒的结合在伤口护理方面具有巨大的潜力，可以增强糖尿病性伤口感染的愈合过程。将抗菌纳米颗粒（如银纳米颗粒（AgNPs）、金纳米颗粒（AuNPs）、铜纳米颗粒（CuNPs）等）与聚合物基质结合可以有效地抑制细菌生长，同时加速伤口的愈合过程。本综述简要介绍了不同天然聚合物和抗菌纳米颗粒的最新发展，以减轻基于糖尿病的 DFU。
