Laser Research Centre, University of Johannesburg, Johannesburg, South Africa.
Laser Research Centre, University of Johannesburg, Johannesburg, South Africa.
Int J Biol Macromol. 2018 Aug;115:165-175. doi: 10.1016/j.ijbiomac.2018.04.003. Epub 2018 Apr 5.
Silver nanoparticles (AgNPs) are classified as metal-based nanoparticles and have gained considerable attention amongst researchers in wound healing applications, owing to their physicochemical and biological properties. Biopolymers are abundantly available from natural sources and are used in numerous applications in pharmaceutical sciences and medicine. Silver nanoparticles and biopolymer-based biomaterials (AgNP-BMs) are non-cytotoxic and safe for patients in wound care management. The unique intrinsic features of AgNP-BMs promote wound healing and effectively control the growth of microorganisms at the wound site, and this strategy plays an important role in the treatment of both acute and chronic wounds. In this review article, we focus on the advanced therapeutic approaches of AgNP-BMs and their potential role in wound healing applications, which includes multifunctional properties, antimicrobial activities and various forms of AgNP-BMs. Moreover, the review briefly recaps on recent progress made in biopolymers, silver, AgNPs and their potential role in clinical research and a commercial platform for the treatment of wounds. Silver nanoparticle and biopolymer-based biomaterial offers a high-degree of biocompatibility and biodegradability in physiological conditions and can be considered as an effective material for wound dressings in the treatment of different wounds.
银纳米粒子（AgNPs）被归类为基于金属的纳米粒子，由于其物理化学和生物特性，在伤口愈合应用方面引起了研究人员的极大关注。生物聚合物大量存在于天然来源中，并在药物科学和医学的众多应用中使用。银纳米粒子和基于生物聚合物的生物材料（AgNP-BMs）对伤口护理管理中的患者无细胞毒性且安全。AgNP-BMs 的独特固有特性促进伤口愈合，并有效地控制伤口部位微生物的生长，这种策略在治疗急性和慢性伤口方面发挥着重要作用。在这篇综述文章中，我们重点介绍了 AgNP-BMs 的先进治疗方法及其在伤口愈合应用中的潜在作用，包括多功能特性、抗菌活性和各种形式的 AgNP-BMs。此外，该综述简要回顾了生物聚合物、银、AgNPs 及其在临床研究和治疗伤口的商业平台中的最新进展。银纳米粒子和基于生物聚合物的生物材料在生理条件下具有高度的生物相容性和可生物降解性，可被认为是治疗不同伤口的伤口敷料的有效材料。
