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红参膳食纤维促进益生菌特性并改变细菌代谢。

Red ginseng dietary fiber promotes probiotic properties of and alters bacterial metabolism.

作者信息

Jeon Hyeon Ji, You Seung-Hwan, Nam Eoun Ho, Truong Van-Long, Bang Ji-Hong, Bae Yeon-Ji, Rarison Razanamanana H G, Kim Sang-Kyu, Jeong Woo-Sik, Jung Young Hoon, Shin Minhye

机构信息

Food and Bio-Industry Research Institute, School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, Republic of Korea.

Laboratory of Efficacy Research, Korea Ginseng Corporation, Daejeon, Republic of Korea.

出版信息

Front Microbiol. 2023 Mar 6;14:1139386. doi: 10.3389/fmicb.2023.1139386. eCollection 2023.

DOI:10.3389/fmicb.2023.1139386
PMID:36950168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10025373/
Abstract

Korean red ginseng has been widely used as an herbal medicine. Red ginseng dietary fiber (RGDF) is a residue of the processed ginseng product but still contains bioactive constituents that can be applied as prebiotics. In this study, we evaluated changes on fermentation profiles and probiotic properties of strains that belong to family with RGDF supplementation. Metabolomic analyses were performed to understand specific mechanisms on the metabolic alteration by RGDF and to discover novel bioactive compounds secreted by the RGDF-supplemented probiotic strain. RGDF supplementation promoted short-chain fatty acid (SCFA) production, carbon source utilization, and gut epithelial adhesion of and inhibited attachment of enteropathogens. Intracellular and extracellular metabolome analyses revealed that RGDF induced metabolic alteration, especially associated with central carbon metabolism, and produced RGDF-specific metabolites secreted by , respectively. Specifically, showed decreases in intracellular metabolites of oleic acid, nicotinic acid, uracil, and glyceric acid, while extracellular secretion of several metabolites including oleic acid, 2-hydroxybutanoic acid, hexanol, and butyl acetate increased. RGDF supplementation had distinct effects on metabolism compared with fructooligosaccharide supplementation. These findings present potential applications of RGDF as prebiotics and bioactive compounds produced by RGDF-supplemented as novel postbiotic metabolites for human disease prevention and treatment.

摘要

韩国红参一直被广泛用作草药。红参膳食纤维（RGDF）是加工人参产品的残留物，但仍含有可作为益生元应用的生物活性成分。在本研究中，我们评估了添加RGDF后属于该家族的菌株的发酵特性和益生菌特性的变化。进行代谢组学分析以了解RGDF引起代谢改变的具体机制，并发现添加RGDF的益生菌菌株分泌的新型生物活性化合物。添加RGDF促进了短链脂肪酸（SCFA）的产生、碳源利用以及[具体菌株]的肠道上皮黏附，并抑制了肠道病原体的附着。细胞内和细胞外代谢组分析表明，RGDF诱导了代谢改变，特别是与中心碳代谢相关的改变，并分别产生了由[具体菌株]分泌的RGDF特异性代谢物。具体而言，[具体菌株]的油酸、烟酸、尿嘧啶和甘油酸的细胞内代谢物减少，而包括油酸、2-羟基丁酸、己醇和乙酸丁酯在内的几种代谢物的细胞外分泌增加。与添加低聚果糖相比，添加RGDF对[具体菌株]的代谢有不同的影响。这些发现展示了RGDF作为益生元的潜在应用，以及添加RGDF的[具体菌株]产生的生物活性化合物作为用于人类疾病预防和治疗的新型后生元代谢物的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/a8987833f109/fmicb-14-1139386-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/cad82460e42a/fmicb-14-1139386-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/939152daeb57/fmicb-14-1139386-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/2e0f9d335bc8/fmicb-14-1139386-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/860c9d937eea/fmicb-14-1139386-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/52152280d07f/fmicb-14-1139386-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/a8987833f109/fmicb-14-1139386-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/cad82460e42a/fmicb-14-1139386-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/939152daeb57/fmicb-14-1139386-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/2e0f9d335bc8/fmicb-14-1139386-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/860c9d937eea/fmicb-14-1139386-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/52152280d07f/fmicb-14-1139386-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/10025373/a8987833f109/fmicb-14-1139386-g006.jpg

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