Hormozi Sirous Faraji, Vasei Narges, Aminianfar Mohammad, Darvishi Mohammad, Saeedi Ali Asghar
Infectious Diseases and Tropical Medicine Research Center (IDTMRC), AJA University of Medical Sciences, Tehran, Iran.
Department of Surgery, Besat Hospital, AJA University of Medical Sciences, Tehran, Iran.
Eur J Transl Myol. 2018 Jul 16;28(3):7594. doi: 10.4081/ejtm.2018.7594. eCollection 2018 Jul 10.
This study was performed to determine the trend of antibiotic resistance of the causative organisms among the patients suffering from nosocomial infections in Besat Hospital since 2013 to 2015. In this observational study that was performed as a retrospective cohort, 935 consecutive patients with nosocomial infection were enrolled in Besat Hospital since 2013 to 2015. The trend of antibiotic resistance of the causative organisms among them was determined and contributing factors were assessed. The finding of this study revealed that type of microorganisms had significant variation (p = 0.024): while the gram-negative bacilli have shown an increased level of resistance, the gram positive cocci had less resistance. The antibiotic resistance was increased for ampicillin/sulbactam, piperacillin/tazoactam, ceftriaxone, ceftazidime, cefepime, meropenem, gentamicin, amikacin, ciprofloxacine, levofloxacine, nitrofurantoin, and ampicilline. However, it was decreased for colistin. In conclusion, antibiotic resistance has an increasing trend and strategic measures of prevention are needed to reduce nosocomial infections.
本研究旨在确定2013年至2015年期间贝萨特医院医院感染患者中病原体的抗生素耐药性趋势。在这项作为回顾性队列进行的观察性研究中，2013年至2015年期间，贝萨特医院连续纳入了935例医院感染患者。确定了其中病原体的抗生素耐药性趋势，并评估了相关影响因素。本研究结果显示，微生物类型存在显著差异（p = 0.024）：革兰氏阴性杆菌的耐药性水平有所上升，而革兰氏阳性球菌的耐药性较低。氨苄西林/舒巴坦、哌拉西林/他唑巴坦、头孢曲松、头孢他啶、头孢吡肟、美罗培南、庆大霉素、阿米卡星、环丙沙星、左氧氟沙星、呋喃妥因和氨苄西林的抗生素耐药性增加。然而，黏菌素的耐药性降低。总之，抗生素耐药性呈上升趋势，需要采取战略预防措施以减少医院感染。
