University Medical Center Groningen , University of Groningen , Antonius Deusinglaan 1 , 9713 AW Groningen , The Netherlands.
Anal Chem. 2018 Nov 20;90(22):13506-13513. doi: 10.1021/acs.analchem.8b03431. Epub 2018 Oct 31.
One of the theories aiming to explain cellular aging is the free radical theory of aging, which describes the possible role of increased production and accumulation of free radicals. Fluorescent nanodiamonds (FNDs) are proposed to provide a tool to detect these radicals, as they function as magnetic sensors that change their optical properties depending on their magnetic surrounding. Therefore, they could enable the study of aging at a molecular level and unravel the exact role of free radicals in this process. In this study, important steps toward this goal are made. FNDs are introduced in chronologically aging yeast cells. Furthermore, the behavior of FNDs in these aging cells is studied to demonstrate the potency of using FNDs in the search for causes of cellular aging.
一种解释细胞衰老的理论是自由基衰老理论，该理论描述了自由基产生和积累增加的可能作用。荧光纳米金刚石 (FND) 被提议作为一种工具来检测这些自由基，因为它们作为磁传感器起作用，根据其磁环境改变其光学性质。因此，它们可以使在分子水平上研究衰老，并揭示自由基在这一过程中的确切作用。在这项研究中，朝着这一目标迈出了重要的一步。FND 被引入到按时间顺序老化的酵母细胞中。此外，还研究了 FND 在这些衰老细胞中的行为，以证明在寻找细胞衰老原因时使用 FND 的潜力。
