Castrucci G, Frigeri F, Angelillo V, Ferrari M, Cilli V, Aldrovandi V
Eur J Epidemiol. 1987 Mar;3(1):5-9. doi: 10.1007/BF00145064.
Field trials were conducted using an inactivated rotavirus vaccine for prevention of calf neonatal diarrhea. For the trials, 458 pregnant cows from 26 herds were involved. In each herd, cows which had been inseminated within a period of two months were selected and randomly subdivided in two groups. Cows in one group (248 head in total) were vaccinated 6 weeks before calving and again 4 weeks later; cows in the other group (210 head in total) were left as unvaccinated controls. At calving, colostrum was collected from each cow and stored at -30 degrees C until used for feeding calves. The newborn calves, beginning the second day of life and for the next 7-10 consecutive days, each was fed a daily supplement of 400 ml of colostrum from its dam. The diarrhea occurred in 86 (40.9%) calves that had received colostrum from unvaccinated dams (normal colostrum), and in 7 (2.8%) calves which were fed colostrum from vaccinated dams (immune colostrum). The disease was very severe in the normal colostrum-fed calves and 52 of them died. Those calves which survived the disease underwent a significant loss of condition. By contrast, the 7 immune colostrum-fed calves displayed a rather mild enteric condition, and all recovered without any sequela being observed.
进行了使用灭活轮状病毒疫苗预防犊牛新生儿腹泻的田间试验。在这些试验中，涉及来自26个牛群的458头怀孕母牛。在每个牛群中，选择在两个月内受孕的母牛并随机分为两组。一组母牛（共248头）在产犊前6周接种疫苗，4周后再次接种；另一组母牛（共210头）作为未接种疫苗的对照。产犊时，从每头母牛收集初乳并储存在-30℃直至用于喂养犊牛。新生犊牛从出生第二天开始，连续7 - 10天，每头每天补充400毫升来自其母亲的初乳。腹泻发生在86头（40.9%）从未接种疫苗的母牛（正常初乳）获得初乳的犊牛中，以及7头（2.8%）从接种疫苗的母牛获得初乳（免疫初乳）的犊牛中。正常初乳喂养的犊牛疾病非常严重，其中52头死亡。那些在疾病中存活下来的犊牛身体状况明显下降。相比之下，7头免疫初乳喂养的犊牛肠道状况相当轻微，并且全部康复，未观察到任何后遗症。
