CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine and i-Lab, CAS Center for Excellence in Brain Science , Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences , Suzhou 215123 China.
School of Nano Technology and Nano Bionics , University of Science and Technology of China , Hefei 230026 China.
ACS Nano. 2018 Oct 23;12(10):9654-9659. doi: 10.1021/acsnano.8b07536. Epub 2018 Oct 15.
The past decade has witnessed rapid technological development on nanoscale probes and imaging optics in the second near-infrared transparency window (NIR-II, 1000-1700 nm). These methods hold great promise for biomedical applications due to their deep penetration through tissues and high fidelity of images. However, applications of these techniques in biomedical research and translational medicine will require a number of issues to be addressed. In this Perspective, we examine the technical challenges for intravital NIR-II fluorescence imaging technology and discuss where the development of this cutting-edge technique fits in the future.
过去十年见证了纳米尺度探针和近红外二区（NIR-II，1000-1700nm）成像光学技术的飞速发展。由于能够穿透组织并提供高保真度的图像，这些方法在生物医学应用中具有广阔的前景。然而，这些技术在生物医学研究和转化医学中的应用需要解决一系列问题。在这篇观点文章中，我们研究了活体 NIR-II 荧光成像技术的技术挑战，并讨论了这项尖端技术的发展方向。
