Ma Chaoran, Pavlova Milena, Li Junjuan, Liu Ying, Sun Yujie, Huang Zhe, Wu Shouling, Gao Xiang
Department of Nutritional Sciences The Pennsylvania State University University Park Pennsylvania.
Department of Neurology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts.
Ann Clin Transl Neurol. 2018 Aug 18;5(10):1176-1183. doi: 10.1002/acn3.630. eCollection 2018 Oct.
To systematically examine the association between alcohol intake and likelihood of having probable rapid eye movement sleep behavior disorder (pRBD) 6 years later.
The study included 11,905 participants (mean age: 47.7 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury in 2006. We determined pRBD using a validated RBD questionnaire-Hong Kong in 2012. Amounts and types of alcohol intake were collected with questionnaire. Participants were categorized into: nondrinkers, light (women: 0-0.4 servings/day; men: 0-0.9 servings/day), moderate (women: 0.5-1.0 servings/day; men: 1-2 servings/day), and heavy drinkers(women: >1 serving/day; men: >2 servings/day). To examine the alcohol-pRBD relationship, we used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for demographic characteristics, smoking, hypertension, diabetes, physical activity, body mass index, and plasma concentrations of lipids and urate.
Compared with nondrinkers, current drinkers had a 23% higher likelihood of having pRBD (adjusted OR 1.23, 95% CI 1.07-1.59). Both moderate (adjusted OR: 1.53, 95% CI 1.01-2.30) and heavy drinkers (adjusted OR: 1.29, 95% CI 1.00-1.66), but not light drinkers (adjusted OR: 1.16, 95% CI 0.94-1.44), had a significantly higher likelihood of having pRBD, relative to nondrinkers. There was a nonsignificant trend between consumption of each individual alcoholic beverages (i.e., beer, wine, or hard liquor) and higher likelihood of having pRBD (adjusted ORs ranged from 1.11 to 1.49).
Alcohol consumption was associated with a higher likelihood of having pRBD. Future prospective studies with clinically confirmed RBD, large sample size for information on types of alcoholic beverage are warranted.
系统研究饮酒与6年后发生可能的快速眼动睡眠行为障碍（pRBD）可能性之间的关联。
该研究纳入了开滦研究中的11905名参与者（平均年龄：47.7岁），这些参与者在2006年时无中风、癌症、帕金森病、痴呆症和头部损伤。我们在2012年使用经过验证的香港RBD问卷来确定pRBD。通过问卷收集饮酒量和饮酒类型。参与者被分为：不饮酒者、轻度饮酒者（女性：每天0 - 0.4份；男性：每天0 - 0.9份）、中度饮酒者（女性：每天0.5 - 1.0份；男性：每天1 - 2份）和重度饮酒者（女性：每天>1份；男性：每天>2份）。为了研究饮酒与pRBD的关系，我们使用逻辑回归计算比值比（OR）和95%置信区间（CI），并对人口统计学特征、吸烟、高血压、糖尿病、身体活动、体重指数以及血脂和尿酸的血浆浓度进行了调整。
与不饮酒者相比，当前饮酒者发生pRBD的可能性高23%（调整后的OR为1.23，95%CI为1.07 - 1.59）。相对于不饮酒者，中度饮酒者（调整后的OR：1.53，95%CI为1.01 - 2.30）和重度饮酒者（调整后的OR：1.29，95%CI为1.00 - 1.66）发生pRBD的可能性显著更高，但轻度饮酒者（调整后的OR：1.16，95%CI为0.94 - 1.44）并非如此。每种酒精饮料（即啤酒、葡萄酒或烈性酒）的消费量与发生pRBD的较高可能性之间存在不显著的趋势（调整后的OR范围为1.11至1.49）。
饮酒与发生pRBD的较高可能性相关。未来有必要进行临床确诊RBD的前瞻性研究，且要有大样本量以获取酒精饮料类型的信息。
