Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
USAID's ONSE Health Activity, Management Sciences for Health (MSH), Lilongwe, Malawi.
J Glob Health. 2018 Dec;8(2):020419. doi: 10.7189/jogh.08.020419.
The neonatal mortality rate (NMR) in Malawi has remained stagnant at around 27 per 1000 live births over the last 15 years, despite an increase in the uptake of targeted health care interventions. We used the nationally representative 2015/16 Demographic Health Survey data set to evaluate the effect of two types of maternal exposures, namely, lack of access to maternal or intra-partum care services and birth history factors, on the risk of neonatal mortality.
A causal inference approach was used to estimate a population attributable risk parameter for each exposure, adjusting for co-exposures and household, maternal and child-specific covariates. The maternal exposures evaluated were unmet family planning needs, less than 4+ antenatal care visits, lack of institutional delivery or skilled birth attendance, having prior neonatal mortality, short (8-24 months) birth interval preceding the index birth, first pregnancy, and two or more pregnancy outcomes within the preceding five years of the survey interview.
We included 9553 women and their most recent live birth within 3 years of the survey. The sample's overall neonatal mortality rate was 18.5 per 1000 live births. The adjusted population attributable risk for first pregnancies was 3.9/1000 ( < 0.001), while non-institutional deliveries and the shortest preceding birth interval (8-24 months) each had an attributable risk of 1.3/1000 (s = 0.01). Having 2 or more pregnancy outcomes within the last 5 years had an attributable risk of 3/1000 ( = 0.006). Attending less than 4 ANC visits had, a relatively large attributable risk (2.1/1,000), and it was not statistically significant at alpha level 0.05.
Our analysis addresses the gap in the literature on evaluating the effect of these exposures on neonatal mortality in Malawi. It also helps inform programs and current efforts such as the Every Newborn Action 2020 Plan. Increasing access to maternal care interventions has an important role to play in changing the trajectory of neonatal mortality, and women who are at an increased risk may not be receiving adequate care. Recent studies indicate an urgent need to assess gaps in service readiness and quality of care at the antenatal and obstetric care facilities.
尽管有针对性的医疗保健干预措施的利用率有所提高,但过去 15 年来,马拉维的新生儿死亡率(NMR)一直停滞在每 1000 例活产中约 27 例。我们使用全国代表性的 2015/16 年人口健康调查数据集来评估两种类型的产妇暴露因素(即无法获得产妇或分娩期护理服务以及分娩史因素)对新生儿死亡风险的影响。
采用因果推理方法,针对每种暴露因素,估计人群归因风险参数,同时调整共暴露因素以及家庭、产妇和儿童特定的协变量。评估的产妇暴露因素包括未满足的计划生育需求、产前护理次数少于 4 次、非机构分娩或无熟练接生人员、先前有新生儿死亡、本次分娩前的短(8-24 个月)分娩间隔、首次妊娠以及在调查访谈前的五年内有两次或更多次妊娠结局。
我们纳入了 9553 名妇女及其最近在调查前 3 年内的活产儿。样本的整体新生儿死亡率为每 1000 例活产中 18.5 例。首次妊娠的调整后人群归因风险为 3.9/1000( < 0.001),而非机构分娩和最短的前置分娩间隔(8-24 个月)各有 1.3/1000 的归因风险(s = 0.01)。在过去 5 年内有两次或更多次妊娠结局的产妇,其归因风险为 3/1000( = 0.006)。接受的产前护理次数少于 4 次具有较大的归因风险(2.1/1000),但在 0.05 的显著水平下没有统计学意义。
我们的分析解决了文献中关于评估这些暴露因素对马拉维新生儿死亡率影响的空白。它还有助于为母婴保健干预措施的普及提供信息,并为当前的努力(如 2020 年每一个新生儿行动计划)提供参考。增加产妇保健干预措施的可及性对于改变新生儿死亡率的轨迹至关重要,而处于较高风险的妇女可能未得到充分的护理。最近的研究表明,迫切需要评估产前和产科保健设施的服务准备情况和护理质量差距。