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聚多巴胺纳米颗粒递送磷光抗癌铱（III）配合物用于靶向联合光热化疗及热/光声/寿命成像

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal-Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging.

作者信息

Zhang Dong-Yang, Zheng Yue, Zhang Hang, Sun Jing-Hua, Tan Cai-Ping, He Liang, Zhang Wei, Ji Liang-Nian, Mao Zong-Wan

机构信息

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 P. R. China.

出版信息

Adv Sci (Weinh). 2018 Aug 15;5(10):1800581. doi: 10.1002/advs.201800581. eCollection 2018 Oct.

DOI:10.1002/advs.201800581
PMID:30356964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6193176/
Abstract

Recently, phosphorescent iridium complexes have demonstrated great potential as anticancer and imaging agents. Dopamine is a melanin-like mimic of mussel adhesive protein that can self-polymerize to form polydopamine (PDA) nanoparticles that demonstrate favorable biocompatibility, near-infrared absorption, and photothermal effects. Herein, PDA nanoparticles are functionalized with β-cyclodextrin (CD) substitutions, which are further assembled with adamantane-modified arginine-glycine-aspartic acid (Ad-RGD) tripeptides to target integrin-rich tumor cells. The thus formed PDA-CD-RGD nanoparticles can deliver a phosphorescent iridium(III) complexes LysoIr ([Ir(ppy)(l)]PF, ppy = 2-phenylpyridine, L = (1-(2-quinolinyl)-β-carboline) to form a theranostic platform LysoIr@PDA-CD-RGD. It is demonstrated that LysoIr@PDA-CD-RGD can be applied for targeted combined cancer photothermal-chemotherapy and thermal/photoacoustic/two-photon phosphorescence lifetime imaging under both in vitro and in vivo conditions. This work provides a useful strategy to construct multifunctional nanocomposites for the optimization of metal-based anticancer agents for further biomedical applications.

摘要

最近，磷光铱配合物已显示出作为抗癌和成像剂的巨大潜力。多巴胺是贻贝粘附蛋白的黑色素样模拟物，可自聚合形成聚多巴胺（PDA）纳米颗粒，该纳米颗粒具有良好的生物相容性、近红外吸收和光热效应。在此，PDA纳米颗粒用β-环糊精（CD）取代基进行功能化，这些取代基进一步与金刚烷修饰的精氨酸-甘氨酸-天冬氨酸（Ad-RGD）三肽组装，以靶向富含整合素的肿瘤细胞。由此形成的PDA-CD-RGD纳米颗粒可以递送磷光铱（III）配合物LysoIr（[Ir(ppy)(l)]PF，ppy = 2-苯基吡啶，L = （1-(2-喹啉基)-β-咔啉），形成一个诊疗平台LysoIr@PDA-CD-RGD。结果表明，LysoIr@PDA-CD-RGD可用于体外和体内条件下的靶向联合癌症光热化疗以及热/光声/双光子磷光寿命成像。这项工作为构建多功能纳米复合材料提供了一种有用的策略，以优化基于金属的抗癌剂用于进一步的生物医学应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/573bf4f3ef5a/ADVS-5-1800581-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/494074555dab/ADVS-5-1800581-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/ec040e7425e5/ADVS-5-1800581-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/8336696d2019/ADVS-5-1800581-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/1eca0e20571a/ADVS-5-1800581-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/35e28eed401f/ADVS-5-1800581-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/2fa13efc22ad/ADVS-5-1800581-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/ff90f662ccb8/ADVS-5-1800581-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/8f2ba1fc62fd/ADVS-5-1800581-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/573bf4f3ef5a/ADVS-5-1800581-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/494074555dab/ADVS-5-1800581-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/ec040e7425e5/ADVS-5-1800581-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/8336696d2019/ADVS-5-1800581-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/1eca0e20571a/ADVS-5-1800581-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/35e28eed401f/ADVS-5-1800581-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/2fa13efc22ad/ADVS-5-1800581-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/ff90f662ccb8/ADVS-5-1800581-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/8f2ba1fc62fd/ADVS-5-1800581-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5d/6193176/573bf4f3ef5a/ADVS-5-1800581-g008.jpg

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