Räisänen Ismo T, Heikkinen Anna Maria, Siren Eva, Tervahartiala Taina, Gieselmann Dirk-Rolf, van der Schoor Gerrit-Jan, van der Schoor Peter, Sorsa Timo
Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland.
Institute for Molecular Diagnostics (IMOD), Bonner Str. 84, 42697 Solingen, Germany.
Diagnostics (Basel). 2018 Oct 22;8(4):74. doi: 10.3390/diagnostics8040074.
Traditional periodontal disease diagnostics are based mainly on clinical examination and radiographs. They assess only past tissue destruction and provide no information on the current disease status or its future progression. The objective is to find out if an active matrix metalloproteinase-8 (aMMP-8) point-of-care (PoC) test could provide a cost-effective way to get around this limitation. This cross-sectional study used 47 adolescents and 70 adults, who were clinically examined and their aMMP-8 PoC tested. The aMMP-8 PoC test results and patients' treatment need, based on the community periodontal index of treatment needs (CPITN), were compared and analyzed using Fisher's exact test. In terms of CPITN, the aMMP-8 PoC test gave no false positives for both adolescents and adults. All healthy patients got a negative test result, while a positive test result indicated periodontal treatment need correctly. Finally, there was a significant association between a patient's aMMP-8 PoC test result and his/her treatment need ( = 0.001 for adolescents, = 0.001 for adults). In conclusion, more accurate diagnostics of periodontal diseases' activity and progression using an aMMP-8 PoC test may help to reduce oral health care costs by reducing patient overtreatment, improving patient outcome, and reducing the need for complex periodontal therapy.
传统的牙周疾病诊断主要基于临床检查和X光片。它们仅评估过去的组织破坏情况，无法提供有关当前疾病状态或其未来进展的信息。目的是探究活性基质金属蛋白酶-8（aMMP-8）即时检验（PoC）是否能提供一种经济有效的方法来克服这一局限性。这项横断面研究纳入了47名青少年和70名成年人，对他们进行了临床检查并进行了aMMP-8 PoC检测。基于社区牙周治疗需求指数（CPITN），将aMMP-8 PoC检测结果与患者的治疗需求进行比较，并使用Fisher精确检验进行分析。就CPITN而言，aMMP-8 PoC检测在青少年和成年人中均未出现假阳性。所有健康患者的检测结果均为阴性，而阳性检测结果则正确表明了牙周治疗需求。最后，患者的aMMP-8 PoC检测结果与他/她的治疗需求之间存在显著关联（青少年中P = 0.001，成年人中P = 0.001）。总之，使用aMMP-8 PoC检测更准确地诊断牙周疾病的活动和进展，可能有助于通过减少患者过度治疗、改善患者预后以及减少复杂牙周治疗的需求来降低口腔保健成本。
