Department of International Healthcare Administration, Daegu Catholic University, Gyeongsan 38430, Korea.
College of Pharmacy, Keimyung University, Daegu Metropolitan 42601, Korea.
Int J Environ Res Public Health. 2018 Oct 23;15(11):2327. doi: 10.3390/ijerph15112327.
Menopause is associated with depressive symptoms that can significantly affect a woman's quality of life. The objective of this study was to evaluate the association between depression and health-related quality of life (HRQoL) in postmenopausal women. In this cross-sectional descriptive study, participants ( = 3860) were selected from the 2013⁻2015 Korea National Health and Nutrition Examination Survey (KNHANES). The sociodemographic characteristics, medical history of depression, and EQ-5D scores of the participants were obtained from the KNHANES dataset. Age, educational level, and income were associated with HRQoL in these participants. Moreover, depression exerted a considerable influence on HRQoL in postmenopausal women. The adjusted odds ratios in participants with depression for the EQ-5D dimensions were as follows: 5.52 (95% CI = 4.04⁻7.55, < 0.001) for anxiety/depression, 3.86 (95% CI = 2.78⁻5.36, < 0.001) for usual activities, and 2.52 (95% CI = 1.68⁻3.78, < 0.001) for self-care. Our findings suggest a strong association between depression and HRQoL. Hence, preventing the onset or exacerbation of depression may significantly improve quality of life in postmenopausal women.
绝经与抑郁症状相关，这些症状会显著影响女性的生活质量。本研究旨在评估绝经后妇女抑郁与健康相关生活质量（HRQoL）之间的关系。在这项横断面描述性研究中，参与者（n=3860）是从 2013-2015 年韩国国家健康和营养检查调查（KNHANES）中选取的。参与者的社会人口统计学特征、抑郁病史和 EQ-5D 评分均来自 KNHANES 数据集。年龄、教育水平和收入与这些参与者的 HRQoL 相关。此外，抑郁对绝经后妇女的 HRQoL 有很大影响。患有抑郁的参与者在 EQ-5D 各维度的调整后比值比（OR）分别为：焦虑/抑郁（95%CI=4.04-7.55， < 0.001）、日常活动（95%CI=2.78-5.36， < 0.001）和自我护理（95%CI=1.68-3.78， < 0.001）。我们的研究结果表明，抑郁与 HRQoL 之间存在密切关联。因此，预防抑郁的发生或加重可能会显著提高绝经后妇女的生活质量。
