靶向非酒精性脂肪性肝病、肥胖症和癌症中脂质代谢的天然化合物的治疗意义。

Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer.

机构信息

Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan 410078, PR China.

Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha, Hunan 410078, PR China.

出版信息

Int J Biol Sci. 2019 Jun 4;15(8):1654-1663. doi: 10.7150/ijbs.33837. eCollection 2019.

DOI:10.7150/ijbs.33837

PMID:31360108

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6643217/

Abstract

Metabolic disorders can lead to a scarcity or excess of certain metabolites such as glucose, lipids, proteins, purines, and metal ions, which provide the biochemical foundation and directly contribute to the etiology of metabolic diseases. Nonalcoholic fatty liver disease, obesity, and cancer are common metabolic disorders closely associated with abnormal lipid metabolism. In this review, we first describe the regulatory machinery of lipid metabolism and its deregulation in metabolic diseases. Next, we enumerate and integrate the mechanism of action of some natural compounds, including terpenoids and flavonoids, to ameliorate the development of metabolic diseases by targeting lipid metabolism. Medicinal natural products have an established history of use in health care and therapy. Natural compounds might provide a good source of potential therapeutic agents for treating or preventing metabolic diseases with lipid metabolic abnormalities.

摘要

代谢紊乱可导致某些代谢物的缺乏或过剩，如葡萄糖、脂质、蛋白质、嘌呤和金属离子等，这些代谢物为代谢性疾病的发生提供了生化基础，并直接促成其发生。非酒精性脂肪性肝病、肥胖症和癌症是常见的代谢紊乱，与脂质代谢异常密切相关。在本综述中，我们首先描述了脂质代谢的调节机制及其在代谢性疾病中的失调。接下来，我们列举并整合了一些天然化合物（包括萜类化合物和类黄酮）的作用机制，这些化合物通过靶向脂质代谢来改善代谢性疾病的发生。药用天然产物在保健和治疗方面有着悠久的应用历史。天然化合物可能为治疗或预防脂质代谢异常的代谢性疾病提供潜在治疗药物的良好来源。