Khalilov Qosimjon, Numonov Sodik, Sukhrobov Parviz, Bobakulov Khayrulla, Sharopov Farukh, Habasi Madina, Zhao Jiangyu, Yuan Tao, Aisa Haji Akber
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
Research Institution "Chinese-Tajik Innovation Center for Natural Products", Ayni str. 299/2, Dushanbe 734063, Tajikistan.
ACS Omega. 2022 Jul 27;7(31):27272-27277. doi: 10.1021/acsomega.2c02165. eCollection 2022 Aug 9.
is a popular medicinal mushroom with diverse pharmacological activities in many Asian countries. Four new triterpenoids, named sulphurenoids A-D (-), along with 12 known analogues, were isolated from the fruits of . Nuclear magnetic resonance, infrared spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques were used for the investigation of the chemical structure of isolated compounds. In addition, the anti-inflammatory activity of three new compounds (-) was tested for NO production in lipopolysaccharide-induced RAW 264.7 cells. The IC values of isolated triterpenoids ranged from 14.3 to 42.3 μM, which were more effective than the positive control (IC for minocycline was 73.0 μM). The experimentally obtained anti-inflammatory activity data of are in agreement with its traditional use.
在许多亚洲国家，它是一种具有多种药理活性的受欢迎的药用蘑菇。从其果实中分离出四种新的三萜类化合物，命名为硫环素A-D（-），以及12种已知类似物。利用核磁共振、红外光谱和高分辨率电喷雾电离质谱（HR-ESI-MS）技术对分离出的化合物的化学结构进行了研究。此外，测试了三种新化合物（-）对脂多糖诱导的RAW 264.7细胞中一氧化氮产生的抗炎活性。分离出的三萜类化合物的IC值范围为14.3至42.3μM，比阳性对照（米诺环素的IC为73.0μM）更有效。实验获得的抗炎活性数据与其传统用途一致。
