Nabipour Hafezeh, Rohani Sohrab
Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
Nanomaterials (Basel). 2024 Aug 23;14(17):1379. doi: 10.3390/nano14171379.
The blood-brain barrier (BBB) plays a vital role in safeguarding the central nervous system by selectively controlling the movement of substances between the bloodstream and the brain, presenting a substantial obstacle for the administration of therapeutic agents to the brain. Recent breakthroughs in nanoparticle-based delivery systems, particularly metal-organic frameworks (MOFs), provide promising solutions for addressing the BBB. MOFs have become valuable tools in delivering medications to the brain with their ability to efficiently load drugs, release them over time, and modify their surface properties. This review focuses on the recent advancements in molecular-based approaches for treating brain disorders, such as glioblastoma multiforme, stroke, Parkinson's disease, and Alzheimer's disease. This paper highlights the significant impact of MOFs in overcoming the shortcomings of conventional brain drug delivery techniques and provides valuable insights for future research in the field of neurotherapeutics.
血脑屏障（BBB）通过选择性地控制物质在血液和大脑之间的移动，在保护中枢神经系统方面发挥着至关重要的作用，这给向大脑给药治疗药物带来了巨大障碍。基于纳米颗粒的递送系统，特别是金属有机框架（MOF）的最新突破，为解决血脑屏障问题提供了有前景的解决方案。MOF凭借其有效负载药物、随时间释放药物以及修饰其表面性质的能力，已成为向大脑递送药物的有价值工具。本综述聚焦于基于分子的治疗脑部疾病（如多形性胶质母细胞瘤、中风、帕金森病和阿尔茨海默病）方法的最新进展。本文强调了MOF在克服传统脑药物递送技术缺点方面的重大影响，并为神经治疗领域的未来研究提供了有价值的见解。
