BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Nucleic Acids Res. 2019 Jan 8;47(D1):D170-D174. doi: 10.1093/nar/gky1026.
RNA editing plays an important role in plant development and growth, enlisting a number of editing factors in the editing process and accordingly revealing the diversity of plant editosomes for RNA editing. However, there is no resource available thus far that integrates editosome data for a variety of plants. Here, we present Plant Editosome Database (PED; http://bigd.big.ac.cn/ped), a curated database of RNA editosome in plants that is dedicated to the curation, integration and standardization of plant editosome data. Unlike extant relevant databases, PED incorporates high-quality editosome data manually curated from related publications and organelle genome annotations. In the current version, PED integrates a complete collection of 98 RNA editing factors and 20 836 RNA editing events, covering 203 organelle genes and 1621 associated species. In addition, it contains functional effects of editing factors in regulating plant phenotypes and includes detailed experimental evidence. Together, PED serves as an important resource to help researchers investigate the RNA editing process across a wide range of plants and thus would be of broad utility for the global plant research community.
RNA 编辑在植物的发育和生长中起着重要作用,它在编辑过程中招募了许多编辑因子,从而揭示了植物编辑体在 RNA 编辑中的多样性。然而,目前还没有一个资源整合了各种植物的编辑体数据。在这里,我们展示了植物编辑体数据库(PED;http://bigd.big.ac.cn/ped),这是一个专门针对植物 RNA 编辑体的经过精心整理的数据库,致力于编辑体数据的整理、整合和标准化。与现有的相关数据库不同,PED 整合了从相关出版物和细胞器基因组注释中手动整理的高质量编辑体数据。在当前版本中,PED 整合了一套完整的 98 个 RNA 编辑因子和 20366 个 RNA 编辑事件,涵盖了 203 个细胞器基因和 1621 个相关物种。此外,它还包含了编辑因子在调节植物表型方面的功能效应,并包含了详细的实验证据。总之,PED 是一个重要的资源,可以帮助研究人员研究广泛的植物中的 RNA 编辑过程,因此对于全球植物研究界具有广泛的应用价值。