State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, PR China.
J Antibiot (Tokyo). 2019 Feb;72(2):111-113. doi: 10.1038/s41429-018-0110-7. Epub 2018 Oct 26.
Curvulaide A (1), a new bicyclic polyketide, together with its known congener preussilide D, were produced by solid-state fermentation with Curvularia sp. IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data, high resolution electrospray ionization mass spectrometry (HRESIMS), experimental and calculated electronic circular dichroism (ECD) spectra. Curvulaide A (1) exhibited moderate anti-anaerobic bacteria activity against periodontal pathogen Porphyromonas gingivalis with the MIC value of 62.5 μM, and showed moderate cytotoxicity against human hepatoma cell lines BEL7402/5-Fu with IC values of 12.46 μM.
环曲霉素 A（1）是一种新的双环聚酮化合物，与已知的同系物普雷乌斯利德 D 一起，由 Curvularia sp. IFB-Z10 通过固态发酵产生。通过光谱方法（包括广泛的一维（1D）和二维（2D）核磁共振（NMR）数据、高分辨率电喷雾电离质谱（HRESIMS）、实验和计算的电子圆二色性（ECD）光谱）组合阐明了 1 的结构。环曲霉素 A（1）对牙周病原体牙龈卟啉单胞菌表现出中等的抗厌氧菌活性，MIC 值为 62.5 μM，对人肝癌细胞系 BEL7402/5-Fu 表现出中等的细胞毒性，IC 值为 12.46 μM。
