IP 受体和钙库操纵性钙内流：填充的许可证。
IP receptors and store-operated Ca entry: a license to fill.
机构信息
Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK.
Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.
出版信息
Curr Opin Cell Biol. 2019 Apr;57:1-7. doi: 10.1016/j.ceb.2018.10.001. Epub 2018 Oct 24.
Inositol 1,4,5-trisphosphate receptors (IPRs) are widely expressed intracellular Ca channels that evoke large local increases in cytosolic Ca concentration. By depleting the ER of Ca, IPRs also activate store-operated Ca entry (SOCE). Immobile IPRs close to the plasma membrane (PM) are the only IPRs that respond to physiological stimuli. The association of these 'licensed' IPRs with the ER-PM junctions where STIM interacts with Orai PM Ca channels may define the autonomous functional unit for SOCE. Ca entering cells through SOCE can be delivered directly to specific effectors, or it may reach them only after the Ca has been sequestered by the ER and then released through IPRs. This 'tunnelling' of Ca through the ER to IPRs selectively delivers Ca to different effectors.
肌醇 1,4,5-三磷酸受体（IPRs）是广泛表达的细胞内 Ca 通道，可引发细胞溶质 Ca 浓度的大幅局部增加。通过耗尽内质网（ER）中的 Ca，IPRs 还会激活储存操纵的 Ca 内流（SOCE）。靠近质膜（PM）的不可移动的 IPR 是唯一对生理刺激做出反应的 IPR。这些“许可”的 IPR 与内质网-质膜（ER-PM）连接处的 STIM 与 Orai PM Ca 通道相互作用，可能定义了 SOCE 的自主功能单位。通过 SOCE 进入细胞的 Ca 可以直接传递给特定的效应器，或者在 Ca 被 ER 摄取并通过 IPR 释放后才能到达它们。这种通过 ER 向 IPR 的“隧道”Ca 选择性地将 Ca 传递给不同的效应器。
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